Concentrated Honeysuckle Developed

The distilled concentrated honeysuckle originally is a medicinal prescription,which the people welcome in the summer season.In order to enhance the medicine the biological exploitability,to carry and totake in this article makes it the oral Solution,Simultaneously systematically studies the improvement preparation procedure,the quality standard make it to become highly effective and stable the controllable modern Formulations.At present,the maim problems of traditional Chinese medicine preparations are much of the Herbs,cruding extraction and invalid ingredients.Preparation technology is simple, preparation is single and backward.Taking is large and useless,times of taking are much. Bioavailability is low and slow.Get HP-β-CD and effective material of Honeysuckle together,make fast effction."Honeysuckle,is good at detoxification,so it is used to cure carbuncle,enlargement and ringworm..." Since ancient times Honeysuckle is used to lowing heat and detoxificating,curing heating and so on.Honeysuckle is full of trace elements and chemical composition,which also has Enzyme.Honeysuckle has the effectiveness of anti-aging,anti-cancer.HP-β-CD isβ-CD Hydroxypropyl derivatives.HP-β-CD is also amorpHous and easily solubled in water.Thermal stability is high.It has a cavity to incluse drug.So it is used to increase solubility and stability.HP-β-CD is a low toxicity,safe,effective drug solvent.Even don't have precipitationin.High concentration inclused drug release fast in the body,and get a high use in bioavailability.HP-β-CD has litte stimulation to the stomach,intestinal and local organizations.It could't be absorpted after taking and saved.Its concentration can reach 40%in clinical,so it has advantage in improving solubility and bioavailability.HP-β-CD and other CD derivatives has the benefits of low price,stability,easily recovery.Preparation procedure:1.Honeysuckle volatiled oil extraction technology:By steam distillation of volatiled oil extract the honeysuckle.We do the experiment by three factors such as canadian water,extraction time,soaking time.The oil content is indicated. So determine the optimal extraction process is:12 times the volume of water;Soak 30 minutes;extraction of six hours.2.Honeysuckle volatile oil solubilization Technology:Use the utilization of oil and the solubilization for targets.To determine the solubilization Technology:30%of the hp-β-cd of concentration,HP-β-CD and volatiled oil ratio of 1:20,Ultrasound time for five minutes.3.PHarmaceutical preparations:In this paper,the use of drugs is relatively simple.By using hp-β-cd package can reduce the volatile of honeysuckle,at the same time increase the solubility and improve the stability and bioavailability.We choose the easily carrying and taking formulations.Quality standards:1.Quality standards:This paper established a honeysuckle volatiled oil identification method of TLC,GC volatiled oil.2.Preliminary Stability:Inspected the oral liquid in the quality of medicines.Determine the validity of the goods,do the normal temperature and speed up temperature experiments.The results showed that the quality of goods is stable.