Synthesis. Between Fluoroanisole Process

M-fluoroanisole is an important organic chemical raw material and intermediate, which can be widely used as medicines, pesticides and veterinary products, especially it can be synthesized into quinolone antimicrobial agents and liquid crystal contained fluorine. The former has been developed to the fourth, which has great medicine activity and durative because of the fluorine. The m-fluoroanisole has broad market prospects.The synthesis of m-fluoroanisole was investigated and improved in this paper. M-Fluoroanisole was synthesized from m-aminophenol by acetylation, methylation, alkalihydrolysis and Balz-Schienamm reaction. Firstly, m-aminophenol reacted with acetic anhydride to protect the amidogen. Then m-methoxy-anisole was obtained by using DMS as the methylized agent in alkaline system. Then m-methoxy-benzenamine was gained through alkalihydrolysis. Finally, m-fluoroanisole was obtained through Balz-Schiemann reaction and decomposed the diazotization in CCl₄. The total yield is 61.6%. The yield of the co-reaction of methylation and alkalihydrolysis was improved by 10% and the yield of the decomposition in the organic solution was improved by 9% respectively. The dissertation made a research on the following factors such as reaction temperature, time, catalyst and the sequence of the materials. Finally, the single factor to consummate the technological process and technological condition was introduced, and the optimal process parameters were got. The product can be determined by the ways of analysis such as IR,MS,GC-MS and HPLC.The process for the production with high collection and low-cost, predigested operation, small industrial pollution, will have broad market prospects.