The Relationship Between Xrcc1 Polymorphisms And The Risk Of Cervical Cancer In Jiangsu Population

Cervical cancer is the second most common cancer among women worldwide after breast cancer, and its high fatality rate seriously imperil the health of people. Nowadays the incidence of cervical cancer is continually increasing in China and the new cases are younger than before. In our country there are about 13 thousands new cervical cancer cases and about 2 thousands to 3 thousands cases who died of this cancer every year .The exact etiology of cervical cancer is intricate, though many studies have suggested that environmental and genetic factors may play important roles. Therefore, it is urgent to clarify the mechanism of cervical cancer development and take effective prevention measures. To reach this target, a hospital-based molecular epidemiological study on cervical cancer was conducted in Jiangsu Province.Objective: To explore the association of XRCC1 gene single nucleotide polymorphisms and the risk of cervical cancer.Methods: In a hospital-based case-control study of 436 patients with newly diagnosed cervical carcinoma and 503 cancer-free controls frequency-matched by age (±5 years), we genotyped the -77T>C and Arg399Glu polymorphisms of XRCC1 gene by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We further analyzed the relationship between cervical cancer and age, menarche age, parity.Results: We found that the -77T>C variant genotypes were associated with significantly decreased risk of cervical cancer [adjusted odds ratio (OR)=0.64; 95% confidence interval (CI)=0.48-0.86], compared with the wild-type homozygote. Moreover, individuals with 3-4 risk alleles increased the risk of cervical cancer accompanied with older age (>50 years) (OR=1.64, 95%CI=1.02-2.64) and parity (OR=1.66, 95%CI=1.01-2.72). By contrast, no significant association was observed between the Arg399Gln polymorphism and cervical cancer risk. Conclusions: Our finding indicated that the XRCC1 -77 CC/CT genotype was significantly associated with a decreased risk of cervical cancer in Jiangsu population.