Relationship Among Serum Interleukin-6 And High Sensitive C Reactive Protein And Metabolic Syndrome In Kazakh And Han In Shihezi And The Surrounding Area

Objective To investigate the situation of metabolic syndrome in Kazakh and Han in Shihezi and the surrounding area, and to explore the relationship among IL-6, hsCRP and MS.Method The participants were 1444 Kazakhs and 2206 Han nationalities, with the method of cluster sampling from Shihezi and the surrounding area in Xinjiang, through Questionnaire-based survey, physical examination and blood testing .At the basis of prevalence survey, sampling 195 and 213 MS patients as the case in Kazakh and Han, and sampling 120 and 201 subjects for matched control from the date. The concentration of serum IL-6 was measured by enzyme linked immunosorbent assay (ELISA), serum hsCRP level by immunoturbidimetric assay (ITM), and serum FINS by radioimmunoassay. Data was managed and inputted with software of Epidata3.02. All statistical analyses were performed using the SPSS13.0 statistical software.Results1. Prevalence rate: In accordance with the IDF, Kazakh's prevalence rate was 32.5%(male 29.0%,female 34.9%),Han's prevalence rate was 25.3%(male 23.0%,female 26.9%),The standardized prevalence rate in Kazakh was 21.11%(male 19.11%,female 23.14%),in Han was 20.65%(male 19.37%,female 22.75%).2. The prevalence rate of obesity: Kazakh and Han (51.7% vs. 43.4%, P<0.05); The prevalence rates of hypertension: Kazakh and Han (54.0% vs. 50.6%, P<0.05); The prevalence rates of hyperglycemia: Kazakh and Han (33.5% vs. 25.0%, P<0.05); The prevalence rate of high TG: Kazakh and Han (9.61% vs. 34.5%, P<0.05); the prevalence rate of low HDL-C: Kazakh and Han (38.1% vs. 30.8%, P<0.05); the prevalence rates of blood-fat abnormality: Han and Kazakh (60.6% vs. 62.1%, P<0.05).3. Serum IL-6 concentration in MS groups were higher than control groups in Kazakh and Han [(1.98±0.52 vs. 1.71±0.61, P Kazakh <0.05) ; (1.50±0.45 vs.1.30±0.52, P Han<0.05)].4. Serum hsCRP concentration in MS groups were higher than control groups in Kazakh and Han [(0.46±0.34 vs.0.19±0.27, P Kazakh <0.05) ; (0.27±0.26 vs.0.08±0.22, P Han<0.05)].5.The level of IL-6 and hsCRP elevated as the increasing numbers of MS component in Kazakh and Han.6.Correlation analysis showed that IL-6 was positively correlated with hsCRP in Kazakh and Han. In Kazakh,IL-6 and hsCRP was positively correlated with age, BMI,WC,WHR,TC,TG,LDL-C,FINS, HMOA-IR and FPG, and negative correlation with HDL-C, hsCRP was positively correlated with age, weight,BMI,WC,WHR, SBP,DBP, TG,FPG,LDL-C,TC,FINSand HMOA-IR, and negative correlation with hight and HDL-C;In Han,IL-6 and hsCRP were positively correlated with weight,BMI,WC,WHR,SBP, DBP,TG,FPG, LDL-C,TC,FINS and HMOA-IR, and negative correlation with HDL-C,otherwise,IL-6 was positively correlated with age in Han MS group.Conclusion 1.The prevalence rates of MS are high among Kazakh and Han, especially in Kazakh women;2. Serum IL-6 and hsCRP concentration in MS groups were higher than control groups; this suggested that there was chronic inflammatory state existed.3. The level of serum IL-6 and hsCRP might be associated with obesity, HMOA-IR and blood-fat abnormality.4. In Kazakh, Serum IL-6 and hsCRP concentration had higher influence to MS than Han.