Expression And Clinical Significance Of Mia2 And Vegf In Primary Hepatocellular Carcinoma

Objective (1)To study the expressions of melanoma inhibitory activity 2 (MIA2) and vascular endothlial growth factor(VEGF) in primary hepatocellular carcinoma (HCC)(2) To explore the correlation between MIA2 and VEGF of hepatocellular carcinoma. Methods 36 paraffin embedded tissues from hepatocellular carcimomas and 29 peficanc- erous tissues which were excised by department of surgery of 1st hospital of NXMEDU during 2004-2008 were collected in the research.By the means of immunohistochemical S-P method,we try to find out the expression,significance and correlation of MIA2 and VEGF both in hepatocellular carcimomas and peficancerous tissues.Results1.The positive expression rate of MIA2 in hepatocellular carcinoma tissues and peficancerous tissues were 41.7%(15/36) and 93.1%(27/29),with significant difference(X~2=18.586,P<0. 05).The expression of MIA2 in hepatocellular carcinoma was related to the TNM staging ,differentiation , and metastases in HCC(P<0.05).2.The positive expression rate of VEGF in hepatocellular carcinoma tissues and peficancerous tissues were 77.8%(28/36) and 34.5%(10/29),with significant difference (X~2=12. 398,P<0. 05).The expression of VEGF in hepatocellular carcinoma was related to the metastasis(P<0.05).3. The expression of MIA2 and VEGF were negative correlation with significant difference(r=-0.497,P<0.05).Conclusion MIA2 expression decreased or vanished in HCC compared with adjacent noncancerous tissues, and closely associated with differentiation, TNM staging and metastases in HCC, it indicated that the decreased expression of MIA2 was closely associated with the development of HCC. VEGF expression in HCC tissues was significantly higher than adjacent tissues, and related to the metastasis; The negative correlation of MIA2 and VEGF indicated that the deletion in expression of MIA2 increased the possibility of the metastasis of hepatocellular carcinoma.