The Clinical Research On Influence Of The Sedation Effects Of Propofol Administered By Tci In Patients With Alcohol Intake

Objective:This study was designed to investigate the drinking information and combined diseases of surgery patients and the influence of patients with chronic alcohol intake on propofol pharmacodynamics and provide theoretical fundation to individualize their anaesthesia policy. Methods:Following Ethical Committee approval of First Affiliated Hospital of Xinjiang Medical university, seventy-one ASA (American Society of Anesthesiologists)Ⅰ~Ⅱpatients, aged 18~59 years, scheduled for undergoing elective surgery under general anesthesia were enrolled in this study and according to two independed-sample t test, they were devided into two groups: drinking group(group D,n=38), non-drinking group(group N,n=33). They were all sedated by received propofol without any other drugs and harmful stimulus before surgery avoid to interaction, and the target plasma concentration of TCI(Target-controlled infusion) was 3.5μg/ml. We monitored and recorded NIBP(Non-invasive Blood Pressure), HR (heart rate), SPO2 (pulse blood oxygen saturation), RE(Response Entropy), SE(state Entropy), the OAA/S(the Modified Observer′s Assessment of Alertness/Sedation) scale, the target plasma concentration of propofol after stopping TCI, the target effect conpartment concentration of propofol, as well as the time of OAA/S scale was 0, the dosage(mg/kg) of propofol at OAA/S was 0, the time of OAA/S return to 5 in two groups. Results: Result suggests patients in group D are chronic long-term alcohol intakers, and without any other combined diseases. The time of OAA/S scale reach 0 in group D (402±198 seconds) was shorter 101 seconds than in group N(503±255 seconds); The dosage of propofol when OAA/S scale reach 0 in group D(2.131±0.663mg/kg) was less 0.266 mg/kg than in group N(2.397±0.746mg/kg); The time of OAA/S return to 5 in group D(481±184 seconds) was shorter 40 seconds than in group N(521±166seconds). Results suggest that there was no significant statistical difference during and after TCI between two groups(P>0.05). The changes of RE and SE were no difference in two groups. There were no difference in changes of HR, SpO2 and NIBP between two groups. There percent of OAA/S reach 0 was 96.97% in group N and 89.47% in group D. Conclusion: The drinking conditions of surgery patients are much better than what we think. Patients with average alcohol intake about 9.5g/d, drinking years about 22.25years, the degree of alcohol intake was 50 in group D compared with group N, the sedation effects of propofol by TCI at 3.5μg/ml under the same conditions are no significant difference.