Spatiotemporal Patterns Of Magnetic Source Imaging Of Patients With Depression Recognition Of Dynamic Facial Expressions

Posted on:2011-02-23

Degree:Master

Type:Thesis

Country:China

Candidate:Y L Han

Full Text:PDF

GTID:2204330302455981

Subject:Mental Illness and Mental Health

Abstract/Summary:

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Background: The mechanism of depression is still unclear, the typical clinical character presents emotion disorder. These impairments and biases in the processing of emotional and social stimuli may underlie problems in mood and interpersonal behavior, and contribute to the onset and maintenance of mood disorders. For these reasons,understanding the mechanisms of the emotion processing abnormalities and identifying brain functional correlates of antidepressant treatment may prove to be helpful in the diagnosis, treatment, and prevention of mood disorders.Objective: To explore the features of functional networks about recognizing dynamical expression with using the spatial and temporal model with magnetoencephalography (MEG) technology and the paradigm of expressional experiment, and further to examine its neurological basis.Methods: 23 Chinese right-handed patients with major depression and 23 volunteers underwent MEG while recognizing dynamical expression videos. Healthy individuals were matched for age, sex and educational levels with major depression,and negative family history. When examined by MEG, all subjects were assessed by WCST. The datas are processed by the softwares as SPM8, Wfu, Marsbar, xjView, SPSS11.5 to statistical analyze.Results:1. The scores of WCSTDepression performance overall worse than the control group, total responses, error responses, significantly more than the healthy comparison participants (P<0.05), and completed categories, sustained responses, significant and persistent errors conceptualize levels were less than the normal control group (P<0.05). Compared with depression without antidepressant treatment, depression with antidepressant treatment performance improved significantly. Compared with depression without antidepressant treatment, the number of error responses of depression with antidepressant treatment is significantly less (P<0.05), and completed categories, the number of sustained response and the conceptual level are more (P<0.05).2. The Data of BehaviorCompared with healthy comparison participants, the total time in recognition of dynamical expression in depression was significantly longer (t=10.82, P<0.000), the time in recognition of dynamically neutral, sadness, happiness, the cross reaction time was significantly longer than healthy comparison participants (P<0.05). the total time in recognition of dynamical expression in depression with antidepressant treatment was significantly shorter (t=3.371, P = 0.002). Including, the times in recognition of dynamically sadness, happiness changes significantly (P<0.05); the length of reaction times after antidepressant treatment were followed neutral>happiness>sadness> cross.3. The result of MEG3.1 The differences of brain activation between patients with depression and healthy comparison participants in recognition of dynamically sadness expressionIn comparison with healthy comparison participants, depression showed increased activation during different time periods were separately as follows: right uncus gyrus, right hippocampusâ†’right superior temporal gyrusâ†’right uncus gyrusâ†’right temporal sub-gyrusâ†’right temporal sub-gyrus, right uncus gyrus, right fusiform gyrusâ†’right inferior temporal gyrus, left corpus callosumâ†’right uncus gyrusâ†’right inferior temporal gyrus, right parahippocampal gyrusâ†’right uncus gyrusâ†’right superior temporal gyrusâ†’right uncus gyrusâ†’right uncus gyrusâ†’right superior temporal gyrus in recognition of dynamically sadness expression.In comparison with healthy comparison participants, depression showed decreased activation during different time periods were separately as follows: right superior temporal gyrusâ†’right claustrum, right insula, right superior temporal gyrus, left insula, left cuneusâ†’left cuneus, left superior temporal gyrus, right superior temporal gyrus, right claustrum, right insulaâ†’left middle occipital gyrus, right superior temporal gyrus, right insulaâ†’left cuneus, left middle occipital gyrus, right middle occipital gyrusâ†’right temporal transverse gyrus, left precentral gyrusâ†’left middle temporal gyrus, left insula, right middle temporal gyrus, right cuneusâ†’right superior temporal gyrusâ†’left precuneusâ†’left superior temporal gyrus, left precuneusâ†’left superior temporal gyrus, right middle temporal gyrusâ†’left transverse gyrusâ†’left transverse gyrus, left middle temporal gyrus, left insulaâ†’left superior temporal gyrus in recognition of dynamically sadness expression.3.2 The differences of brain activation between patients with depression and healthy comparison participants in recognition of dynamically happiness expressionIn comparison with healthy comparison participants, depression showed increased activation in during different time periods were separately as follows: left cingulate gyrus, right uncus gyrusâ†’right inferior temporal gyrusâ†’left anterior cingulate gyrusâ†’left anterior cingulateâ†’right inferior temporal gyrusâ†’left head of the caudate nucleus, right head of the caudate nucleus, left anterior cingulate gyrusâ†’left inferior frontal gyrus, left anterior cingulate gyrus, left medial frontal gyrusâ†’left inferior frontal gyrusâ†’left inferior frontal gyrusâ†’left inferior frontal gyrus in recognition of dynamically happiness expression.In comparison with healthy comparison participants, depression showed decreased activation in during different time periods were separately as follows: left middle temporal gyrus, right middle occipital gyrusâ†’left middle temporal gyrusâ†’right transverse temporal gyrus, left superior temporal gyrus, left insulaâ†’left middle temporal gyrus, right middle temporal gyrus, right insula, left postcentral gyrusâ†’right middle occipital gyrusâ†’right insula, left inferior frontal gyrusâ†’right insula, right superior temporal gyrusâ†’left middle temporal gyrus, right claustrum, right superior temporal gyrusâ†’right claustrum, right putamen, the right precuneus , right middle temporal gyrusâ†’left superior temporal gyrusâ†’right insula, left claustrum, left precuneusâ†’right claustrum, right insula, right precuneus, left inferior frontal gyrus, left middle temporal gyrusâ†’right insulaâ†’right claustrum in recognition of dynamically happiness expression.3.3 The gender differences of brain activation between patients with depression in recognition of dynamically sadness expressionIn comparison with male depression, female depression showed increased activation in during different time periods were separately as follows: right inferior frontal gyrus, left frontal gyrus, left anterior cingulate gyrus, the left brainstemâ†’right superior frontal gyrus, right middle frontal gyrusâ†’right middle frontal gyrus, left anterior cingulate gyrusâ†’right superior frontal gyrus, left inferior frontal gyrus, left precentral gyrusâ†’right superior frontal gyrus, right inferior frontal gyrus, left superior frontal gyrus, left anterior cingulate gyrusâ†’right precentral gyrus, left anterior cingulate gyrusâ†’right middle frontal gyrus, left brainstemâ†’right middle frontal gyrus, left superior frontal gyrusâ†’right middle frontal gyrus, left hippocampus, left parahippocampal gyrusâ†’right inferior frontal gyrusâ†’right middle frontal gyrusâ†’right middle frontal gyrusâ†’right middle frontal gyrus, right inferior frontal gyrusâ†’right superior frontal gyrus, left claustrum, right middle occipital gyrus in recognition of dynamically sadness expression.In comparison with male depression, female depression showed decreased activation in during different time periods were separately as follows: right superior temporal gyrusâ†’right parahippocampal gyrusâ†’left cuneusâ†’right middle temporal gyrusâ†’right superior temporal gyrusâ†’left precuneus, left middle temporal gyrusâ†’right parahippocampal gyrus in recognition of dynamically sadness expression.3.4 The gender differences of brain activation between patients with depression in recognition of dynamically happiness expressionIn comparison with male depression, female depression showed increased activation in during different time periods were separately as follows: left brain lobeâ†’right occipital gyrusâ†’left brain lobe, left medial frontal gyrusâ†’left brainstemin in recognition of dynamically happiness expression.In comparison with male depression, female depression showed decreased activation in during different time periods were separately as follows: right parahippocampal gyrus, right superior temporal gyrus, left putamen, left uncus gyrusâ†’left inferior frontal gyrus, left putamen, right anterior cerebellum, left superior temporal gyrusâ†’right cerebellar anterior lobe, left superior temporal gyrus, left transverse temporal gyrus, left cuneusâ†’right cerebellar anterior lobe, left cerebellar anterior lobe, left inferior frontal gyrusâ†’left lingual gyrus, left posterior cingulate gyrus, right parahippocampal gyrusâ†’left precuneusâ†’right superior temporal gyrus, right cerebellum anterior lobe, left lingual gyrus, left insulaâ†’right cerebellar anterior lobe, left superior temporal gyrus, left insula, right extra unclearâ†’left superior temporal gyrusâ†’left superior temporal gyrus, right fusiformâ†’left superior temporal gyrusâ†’right fusiform gyrus, left superior temporal gyrus, left cerebellar vermisâ†’left superior temporal gyrus, left insulaâ†’right temporal sub-gyrus, left extra unclear, left fusiform gyrus in recognition of dynamically happiness expression.3.5 The differences of brain activation between patients without antidepressant treatment and patients with antidepressant treatment in recognition of dynamically sadness expressionIn comparison with patients without antidepressant treatment, patients with antidepressant treatment showed increased activation in during different time periods were separately as follows: right cerebellar posterior lobe, postcentral gyrusâ†’left cerebellar posterior lobe, right cuneusâ†’left precuneus, left cuneusâ†’right cuneus, right uncus gyrus, right inferior temporal gyrus, right middle occipital gyrus, right inferior temporal gyrusâ†’right cuneusâ†’right cuneusâ†’right cerebellar posterior lobe, right cuneus, left cuneusâ†’left cerebellar posterior lobeâ†’left cuneusâ†’left inferior occipital gyrusâ†’left inferior occipital gyrus, left medial frontal gyrusâ†’left inferior occipital gyrus, right cuneus, right lingual gyrusâ†’left fusiform gyrus, left middle occipital gyrus, left inferior occipital gyrus, right cuneus, right lingual gyrusâ†’left inferior occipital gyrus, left fusiform gyrus in recognition of dynamically sadness expression.In comparison with patients without antidepressant treatment, patients with antidepressant treatment showed decreased activation in during different time periods were separately as follows: left cerebellar anterior lobeâ†’left cerebellar anterior lobeâ†’right inferior frontal gyrus, left superior temporal gyrus, left cerebellar anterior lobeâ†’left inferior frontal gyrusâ†’right dorsal thalamus core, right anterior thalamic nucleus, right pallidus, right middle temporal gyrusâ†’right middle temporal gyrusâ†’right middle temporal gyrusâ†’right middle temporal gyrusâ†’right middle temporal gyrusâ†’right parahippocampal gyrus, right middle temporal gyrus in recognition of dynamically sadness expression.3.6 The differences of brain activation between patients without antidepressant treatment and patients with antidepressant treatment in recognition of dynamically happiness expressionIn comparison with patients without antidepressant treatment, patients with antidepressant treatment showed increased activation in during different time periods were separately as follows: right cuneus, left precuneus, left cuneusâ†’right posterior cingulate, left precuneusâ†’right precuneusâ†’left precuneusâ†’left cuneus, right lingual gyrusâ†’right cuneusâ†’left cuneus, right cuneus, right middle occipital gyrus, right middle temporal gyrusâ†’cuneusâ†’right cuneusâ†’left cuneus in recognition of dynamically happiness expression.In comparison with patients without antidepressant treatment, patients with antidepressant treatment showed decreased activation in during different time periods were separately as follows: posterior cingulate, right middle frontal gyrus, right putamen, left superior temporal gyrusâ†’right middle frontal gyrus, right inferior frontal gyrus, left middle temporal gyrusâ†’right frontal lobe, left superior temporal gyrusâ†’right inferior frontal gyrusâ†’right lenticular nucleus, right middle frontal gyrus, right inferior frontal gyrus, left lenticular nucleus, left middle frontal gyrusâ†’right middle frontal gyrus, left brainstemâ†’right lenticular nucleus, right middle frontal gyrus, right inferior frontal gyrus, left lenticular nucleus, left middle frontal gyrusâ†’right middle frontal gyrus in recognition of dynamically happiness expression.3.7 The feature of amygdala between patients with depression and healthy comparison participants in recognition of dynamically sadness expressionIn Comparison with healthy comparison participants, the function of amygdala of depression showed abnormal activation were separately as follows: in 50 ~ 150ms, 100 ~ 200ms, 150 ~ 250ms, 300 ~ 400ms, 450 ~ 550ms, 600 ~ 700ms several time periods.In Comparison with healthy comparison participants, the function of left amygdala of depression showed abnormal activation were separately as follows: 50 ~ 150ms, 100 ~ 200ms, 150 ~ 250ms, 300 ~ 400ms, 750 ~ 850ms several time periods.In Comparison with healthy comparison participants, the function of right amygdale of depression showed abnormal activation were separately as follows: 50 ~ 150ms, 100 ~ 200ms, 150 ~ 250ms, 250 ~ 350ms, 300 ~ 400ms, 450 ~ 550ms, 550 ~ 650ms, 600 ~ 700ms, 750 ~ 850ms several time periods.Conclusions: The results of this study indicate that abnormal pathology spatial-temporal model in the emotion processing of facial expressions in depressed patients. The cortical mood regulating regions in patients improved activation in following antidepressant treatment for the response to sadness. But no much difference was found in recognition of happy faces. And the function of right amygdala may be closely associated with mood disorders. These abnormalities may indicate the characteristics of emotional circle in depression, but also further revealed the mechanism of clinical symptoms in depression, to provide the clues for the treatment, prevention in future.

Keywords/Search Tags:

dynamic facial expression, magnetoencephalogram, spatial-temporal pattern, depression, treatment

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