| ObjectiveTo research the warming conditions of skin hyperthermia apparatus at different depths in the mammalian skin, to evaluate the safety of the plasma glow treatment for skin,to research the therapeutic effect of hyperthermia combined with plasma treatment for acne keratosis model of rabbit ears.To provide a scientific basis for the using of hyperthermia and plasma for treatment of skin diseases.Methods1.Heat Agar phantom and skin of rabbits buttock by using skin hyperthermia apparatus:Heat Agar phantom and skin of rabbits buttock respectively by using skin hyperthermia apparatus.To get the warming conditions at different depths in the rabbit skin and provide a reference of skin hyperthermia in clinical trials.2.Assess the the safety of Plasma glow effect on the health rabbit ear:Plasma glow the health rabbit ear by using Plasma generator for seven consecutive days,get the rabbit ear tissue On the eighth day, then histopathological analysis was performed(HE staining).It's biological security was assessed according to the results.3.Hyperthermia combined with plasma treatment for acne model of rabbit ears:makeacne keratosis model of rabbit ears and be sure the model has been created.then the rabbits were divided into six groups:control group,model group,group of retinoic acid,group of hyperthermia,group of plasma treatment,group of hyperthermia combined with plasma treatment.Evaluated effect of hyperthermia combined with plasma treatment for acne keratosis model of rabbit ears by comparing the results.Result1.Heat Agar phantom and skin of rabbits buttock by using skin hyperthermia apparatus:got the curves which express warming conditions at different depths in the rabbit skin,when the temperature of skin hyperthermia apparatus is 48℃,50℃,52℃and 54℃. And simulated the curves which express warming conditions when skin heated by hyperthermia apparatus,at different depths in the rabbit skin,for example,1mm,2mm,3mm,4mm,5mm,7mm under the skin. 2.Assess the the safety of plasma glow effect on the health rabbit ear:observed and recorded the results,combined with histopathological analysis,concluded that plasma glow is safe to the health rabbit ear.3.Hyperthermia combined with plasma treatment for acne model of rabbit ears:compare six experimental groups,both hyperthermia and plasma treatment have certain therapeutic effects for acne keratosis model of rabbit ears.In four grounps of treatment,group of hyperthermia combined with plasma treatment reflect the best effect.the second one is group of hyperthermia. The effects of both groups are better than group of retinoic acid which is in common use for acne.Conclusion1.When skin of rabbits buttock was heated by using skin hyperthermia apparatus,temperture at different depths in the mammalian skin increased simultaneously.What's more,they are regularly.2.Plasma glow for experiment is safe to the health rabbit ear.3.Hyperthermia combined with plasma treatment has visible therapeutic effect for acne keratosis model of rabbit ears. |
PDF Full Text Request