Tumor Magnetic Induction Hyperthermia Novel Magnetic Nano Media

ObjectiveThe research project aims to explore the magnetic induction hyperthermia (MIH) for cancer with the clinical application of novel magnetic nano-media, artificial magnetic nanoparticles prepared by modification of magnetic nanoparticles and natural two-part study its feasibility.MethodsThis research project is divided into two parts:The first part, sub-step preparation of polyethylene glycol-modified iron oxide magnetic nanoparticles amino silane, optimized preparation parameters, so that the final optimized preparation conditions. From the physical and chemical characteriza-tion and biocompatibility in vitro, both for the tumor to evaluate the feasibility of magnetic induction hyperthermia.The second part of the exploration of natural nano-magnetite magnetic induction hyperthermia in tumor feasibility of the application. Physicochemical characterization from the outside, respectively, in vitro biocompat-ibility, in vitro hyperthermia, acute toxicity in vivo comparison of four lev-els of artificial magnetic fluid preparation, evaluation of magnetosomes of magnetic induc-tion hyperthermia for tumor viability. The magnetic bodies in the field of application of targeted cancer therapy provides an effective experimental basis, and the magne-tic induction hyperthermia for cancer provides a new medium and the MIH.Result1) sub-step successfully prepared PEG amino silane modified magnetic iron oxide nanoparticles, and has a high heat rate, good dispersion stability, good bio-safety and biocompatibility.2) Physicochemical characterization in vitro, in vitro biocompatibility, in vitro hyperthermia, in vivo acute toxicity of four levels, the control of artificial magnetic fluid preparation, confirmed magnetosomes of magnetic induction hyperthermia for tumor viability, and relative magnetic Advantage of the fluid. As a new media and the magnetic heat treatment, the magnetosomes of magnetic induction hyperthermia for cancer to provide an effective experimental basis.ConclusionPolyethylene glycol-modified iron oxide magnetic nanoparticles amino silane, the relative modification of magnetic iron oxide is not satisfied. PEG-amino silane modified magnetic nanoparticles have good biocompatibility, applied to the tumor Magnetic induction hyperthermia have demonstrated good feasibility.Magnetosomes as a natural magnetic nanoparticles, prepared by a relatively artificial magnetic fluid, with good magnetic properties, biocompatibility, temperature performance, no cell toxicity. Physicochemical characterization from the outside, Bi ocompatibility, in vitro hyperthermia, four levels of acute toxicity in vivo, confirmed its full magnetic induction hyperthermia for tumor viability.