Strengthening The Foundation Of Cough And Asthma Particles Pharmacodynamic Study

Background: Bronchial Asthma is a common respiratory system disease, which is the chronic airway inflammation induced by combined action of various inflammatory cells, especially mast cells, T lymphocytes and eosnophils, etc.; the inflammation could make susceptible persons to develop recurrent dyspnea, anhelation, chest discomfort, cough, etc., which mainly happen by night or before dawn; these symptoms are often accompanied by generalized versatile expiratory flow limitation, but some could natural relief. Such symptoms are accompanied by a variety of stimulating factor to the airway heighten reactive. Bronchus asthma is one of the most common chronic respiratory disease in current world ,and danger to public health. of Currently 3 billion worldwide have asthma, China an estimated 20 million patients with asthma, has become a serious public health problem, its incidence and mortality in the global scope of show ascendant trend. Chinese medicine for asthma understanding of the main focus on two sides: on one side is ferrite deficiency, and on the other hand, It is "volt phlegm" caused.Purpose: This study of the particle is in favor of cough to smooth wheezing in clinical application process has obtained good curative effect, deeply the general court of the patient high praise preparations. The original optimized, improvement, treatmentresult downsizing, and will improve as granules, exempt for the inconvenience and treatmentresult patients take pain. Consoliated cost cough to smooth wheezing particles is a kind of pure Chinese herbal medicine preparations, the foreman ephedra sinica, ginkgo, walnuts, etc LiuWei Chinese medicine composition, have relatively lung kidney, phlegm, and set the efficacy of pant, attending the bronchus asthma (virtual) of coughing, wheezing promote, bosom frowsty, laryngeal sound, shortness of breath, fatigue, etc card。To evaluate efficacy of Chinese Compound Prescription- Guben granule for treating cough and asthma by pharmacology research and provide foundation for clinical trials and application。Material and method:1.Asthma cavy model was established by sensitization and challenge with ovalbumin, In order to observe the effect of the Guben granule for treating cough and asthma on asthma。2.Weighing of the immunity organs , method of carbon grains purging in mices blood and the determination of hemolysin due to chickens red blood cells were used.3.Using the index of weight loading swimming test, in order to observe the effect of the Guben granule for treating cough and asthma on antifatigue.Results:1.To stimulate with OVA,Guben granule for treating cough and asthma at doses of 2.21g/kg,4.42g/kg,8.84g/kg and the positive control(Dex)were significantly different from the control group(p<0.05).It has antiasthmatic effects,and can decrease the white blood cell counts in serum and BALF.2.Guben granule for treating cough and asthma at doses of 7.42g/kg,14.84g/kg can significantly enhance the phagocytosis of macrophages。3.Guben granule for treating cough and asthma at doses of 14.84g/kg can prolong the time of the rats in weight loading swimming test.Conclusion:Guben granule for treating cough and asthma have been shown to relieving asthma,anti-inflammatory,immunodepression and antifatigue。...