Congenital Heart Disease In Patients With Plasma Nitric Oxide And Its Related Vasodilation Factor Levels And Pulmonary Artery Pressure

Abstract Objective: To study the significant role of the Nitric oxide (NO) and its mediated vasodilator factors such as adrenomedullin (ADM)~ prostacyclin (PGI2) vasoactive intestinal peptide (VIP) and atrial natriuretic peptide (ANP) in pulmonary hypertension and their relationships to pulmonary pressure ,we assayed the plasma levels of NO. ADM~. PGI2 VIP and ANP in congenital heart disease patients (CUD) complicated by pulmonary hypertension and control subjects. Methods: 40 patients with congenital heart disease who would go through surgical treatment were included. According the results of cardiac ultrasound, the subjects were deviled pulmonary hypertension group(PH group, 15 patients)and control group(25 patients). Plasma levels of NO were measured by colorimetric assay. Plasma levels of ADM~ PGI2~ VIP and ANP were measured by specific radioimmunoassay. Results:OThe plasma levels of NO and ADM~. PGI2~ VITh ANP in PH subjects increased significantly in PH subjects than in control subjects, the numbers P are respectively lower than 0.01 ~0.01~ 0.05~ 0.01 and 0.01. 甌he plasma levels of NO, as well as plasma levels of ADM PGI2 VIP and ANP, were notably with *relation to pulmonary arterial systolic pressure, the numbers r were 0.54~ 0.50~ 0.640.49and 0.81 0.01 ~ 0.01 ~. 0.01~ 0.05 and 0.01. 甈lasma levels of ADM~ PGb~. VIP and AN were correlated with plasma levels of NO , the numbers r 5 were 0.45~. 0.49~ 0.39 and 0.41 respectively ,the numbers P were respectively lower than 0.05~ 0.01 ~ 0.05 and 0.05. Conclusion: 0 The plasma levels of NO and its mediated vasodilator factors in CHiD complicated by pulmonary hypertension were increased with the raise of pulmonary pressure. @~There are no cooperative roles and added roles in increasing the plasma levels NO by NO and its mediated vasodilator factors .The escape of NO may be exsisted. 0 The increasment of NO and its mediated vasodilator factors play an important role in delaying of the genesis and development in Cl-ID complicated by pulmonary hypertension. ㏄lasma NO and its mediated vasodilator factors can reflect the seriousness of pulmonary pressure in patients with congenital heart disease . Therefore, plasma Plasma NO and its mediated vasodilator factors may be very important parameters for the prejudges of patients with congenital heart disease.