The Stilbene Normalized Shengjiangsan Clinical Research On The Role Of Lipid Metabolism Disorders In Chronic Renal Failure

Chronic renal failure (CRF) is a kind of common questioned disease as the end stage of many renal pathological changes. To study on a synthetic therapy including Chinese medicine and without hemodialysis to delay the development of CRF is of great importance.The thesis includes two parts, review and clinical research.The review part includes 2 papers. The first one reviewed the modern study on CRF. It introduced pathogenesis of CRF, especially which of the disorder of blood lipid metabolism during the development of CRF, and the non-hemodialysis therapy. The second one was about the modern Chinese medicine study on CRF, including general knowledge of CRF in Chinese medicine, the current awareness on treating CRF with Chinese medicine and the mechanism of the action of Chinese herb.In clinical study part, we selected 63 patients who were all in the early or middle stages of CRF, and divided them into 2 groups randomly and comparably, 32 cases were in subject group, 31 in control group. The subject group patients were treated by basic treatment (including diet control and presCRFbing medicine according to the symptom) and the powder consists of QIGUISHENGJIANGSAN, the control group patients were given basic treatment and Lotensin. To observe the change of HGB, renal function, blood lipid and scores of Chinese medicine symptom, evaluate the curative effect after 12 weeks. Results: In SUBJECT GROUP group, HGB, Ccr and HDL were raised while Scr , BUN, TC,TG and LDL were lowered significantly, in control group, HGB and BUN were lowered significantly, while no remarkable change in blood lipid indexes. In both groups, there were significant improvement in symptom scores, but the effect was better in subject group and there were statistical difference between the 2 groups.The clinical study showed that the powder consists of QIGUISHEGNJIANGSAN could not only improve the clinical symptom, but also better improve anemia, delay the development of CRF in the early and middle stages, regulate the disorder of blood lipid of CRF patients. We inferred that the effect of regulating disorder of blood lipid was one of the probable mechanism in protecting the renal function.