The Yin Bile Pinggan Capsule Pharmaceutics, Quality Standards And Pharmacodynamics

Alcoholic liver injury is the most common pathological change of alcoholic hepatosis (include alcoholic fat liver,alcoholic hepatitis, alcoholic cirrhosis). It is important factor leading to alcoholicci rrhosis. According to western medic i ne, alcohol ic liver di sease's mechanismis a kind of 1 iver trauma caused by the toxicity function of alcohol and its metaholite, 1iver micro-circulation obstruct and the variation of alcohol metabolic enzyme. According to TCM, ALD is treated in phase and type by its characteristic, reason and mechanism, and has obtained some curative effects. We choose Yindan pinggan capsule.We study its process and quality standard. We also study the indication of alcoholic liver injury by Pharmaconamics experiment.The first, Pig s gall powder is extracted.Radix angelicae sinensis'soptimal condition for the process of alcohol extract is established by orthogonal lest.An optimal condition for the process of water extract is established by orthogonal test.To choose the best formula of excipients.To adopt High shear mixer granulator and High boi 1 ing dryer. And using new packi ng material PVDC. The measure reduces the moisture absorption effectively in order to increase the stability of the drug.We also prove the reasonableness, stabil ity and safety of the preparation process by acute toxicity and pharmacodynamic comparing test and the middle scale production. The second, we set up the quality standard, including identification ofPig s gall powder, Fructus gardeniae, Radix paeoniae alba and Radix angelicae sinensis and assay of Radix scutellariae. Largely increasing the quality control level of the drug.Pharmaconamics experiments prove that Yindan pinggan capsule has a certain improvement to liver function and reduced TG on the spleen-deficiency indication of alcoholic hepatosis.And it has a certain improvement to liver function on alcoholic hepatosis. Meanwhile Yindan pinggan capsule has significant protection on the arising of liver MDA in acute poison of little rats.