Nitric Oxide In Brain Ischemia And Reperfusion In The Process Of Diffusion And Reaction Kinetics Studies

Nitric Oxide(NO) is a biological messenger molecule formed via the oxidation of L-arginine to citrulline by various forms of NO synthase. The synthesis of NO is observed in a wide variety of mammalian cells. With the development of NO research , it has been found that NO is associated with many diseases, such as brain ischemia, hypertension, arteriosclerosis, miocardial infarction, coronary heart disease. More knowledges of NO transformation regular rule and NO action mechanism will help us defend and treat these diseases.Based on hypoxia experiments of cultured neurons in vitro, a NO diffusion kinetic mathematical model and a NO reaction kinetic mathematical model has been developed to study the transformation of NO and other relational molecules. With the analysis of NO chemical and physical character and simulation of NO generation in the hypoxia experiment of cultured neuron, a diffusion kinetic model was established to simulate NO diffusion from hippocampus in brain ischemia. With the analysis of chemical reactions about NO in brain ischemia and ischemia-reprefusion, based on hypoxia experiment of culturd neuron in vitro, a reaction kinetic model of neuron was established to simulate complex chemistry of NO, 02, ONOO" in brain ischemia and ischemia-reprefusion. Preliminary discussions about the simulation results were gived.