| Objective To explore the regulating mechanism of Bu sheng Zhuang Gu Capsules (BC) on bone metabolism of Diabetic Osteoporosis (DO) rats models. Methods Established DM rats models by introperitoneal injection of Alloxan. Trended the diabetic rats with condensed liquor of BC and Calcium Carbonate Tablets+Alpha D3 respectively through tube feeding, and Metformin Hydrochloride Tablets as basic remedy meanwhile. Observed the influence of different medicines on following parameters: diabetic general condition , bone mineral density(BMD), bone metabolism biochemical criterion, PTH bone biomechanical property, bone histomorphometry and hemorheology as well Results The experimental DM rats showed apparently abnormal on parameters stated above. After the therapy of BC, the abnormal condition relieved markedly. And the comprehensive action of BC was better than that of west medicines. Conclusion These results suggested that diabetic rats had clearly osteopenia and osteoporosis. BC can modulate effectively the bone metabolism and the bone remodeling of DO rats models through many ways and many links. |
PDF Full Text Request