Chinese Medicine Clinical Research Of Esophageal Regional Lymph Node Micro-metastasis

Investigation Background: Esophageal carcinoma is one of the most familiar malignancy, the prognosis is worse,the reason is that metastasis to lymph nodes are prone to occour.Along with the developing of Pathology and Molecular cell biology, the micrometastasis to lymph nodes are brought forward.this is an important factor in patient of esophageal carcinoma.In order to probe into the mechanism of TCM (Traditional Chinese Medicine) in this domain.So we choice aidi injection ,bestow Traditional Chinese compound Medicine injection--aidi injection to patient of esophageal carcinoma,via observing the ratio of micrometastasis,and comparing with control group,to expected that aidi injection can reduce the ratio of micrometastasis,thereout consummate the colligation treatment of esophageal carcinoma.Methods:To collect 30 patients of esophageal squamous cell carcinoma,the experimental group and the control group are each of 15 cases. Bestow aidi injection to experimental group patients,80ml/d,ivgttx7d;The other therapeutic medicine is similar in two groups.All the patients are not given medicine of chemical therapy and medicine which can influence their immunological function.The two groups are all carried out the similar mode of surgery .After completing ordinary H&E staining detection,pick out the lymph nods that ordinary H&E staining for metastasis are negative.we detect every lymph node using Ckpan and CK16 by SP immunohistochemistry staining to look for micrometastasis to lymph nodes.Results: 7 patients ( 7/15,46.66% ) and 15 lymph nodes (15/186,8.11%) are found to have micrometastasis to lymph nodes,which lymph node metastasis results by H&E staining are all negative in control group;5 patients (5/15,33.33%) and 8 lymph nodes ( 8/318,2.51%) are found to have micrometastasis to lymph nodes,whose lymph node metastasis results by H&E staining are also negative in experimental group.Although no significant difference in statistics is found between the two groups in the positive patient rates,P=0.7088 > 0.05 ' significant difference in statistics is found between the two groups in the positive lymph node rates,P=0.0038 < 0.05 .Conclusion: The traditional Chinese compound preparation-aidi injection Can reduce the detecting ratio of the micrometastasis to lymph nodes in regional lymph nodes in patients with esophageal squamous cell carcinoma.In other words,Aidi injection can eliminate the micrometastasis to lymph nodes,so the injection can decrease the reoccur and metastasis,improve the sufferer' s prognosis.