Premature Ovarian Failure, Influencing Factors, Investigation And Analysis

This study was aimed to determine the potential risk factors for POF, using questionaire survey to 90 POF patients and 224 women with normal menstruation as control group at the first affiliated hospital of Chongqing medical university from 2002 January to 2004 December, to discover the all possible risk factors of POF , trying to find the way to reduce the rate of failure of ovarian function, to change the life quality of POF patients. Results 1. 18 cases (20%) were prior to 29 years old, the remains (80%) were 30~40 years. POF was associated poor familial income(p<0.05), and not associated with height, weight, education level , profession . 2. POF was associated with irregular period in the year before last menstruation (p<0.001),and not associated with age at menarche, menstrual cycle, menstrual period, menstrual volume , and pain .The more artificial aboration ,the higher incidence of POF(OR=2.176,95% confidence interval was 1.068~4.433). Long term using oral contraception may be associated with POF(p<0.05). 3. Smoking was a risk factor of POF, and (OR=3.203,95% confidence interval was 1.460~7.024) but passive smoking may not associated with POF. The more vegetable and bean taking,the lower incidence of POF ( OR=0.313 , 95 % confidence interval was 0.136~0.718). Diet associated with POF, but the quality of sleep was not associated with it. 4. Emotion factor, the relationship with relatives and friends, stress or passive life accident before menopause, were highly associated with POF. Marriage station was a effective factor of POF, divorce or live in single increase the incidence of POF (OR=6.098,95% confidence interval was 1.299~28.621). 5. Hair staining or hairdressing decoration of the house was associated with POF ( Hair staining OR=2.759 , 95 % confidence interval was 1.307~5.821). Computer using and cooking often may be not associated with POF. 6. Having had parotitis was important risk factor of POF( R=10.475 , 95 % confidence interval was 1.200~91.413 ) .Cyclophosphamide, tripterygium glycosides and Huobahua-gen may be associated with POF. Single lateral and bilateral ovarian operation may be associated with POF. Simple uterectomy may be not associated with POF. 7. 14.44% POF patient had family history, POF may be associated with inheritance. 8. Bone mineral density determine indicated the incidence rate of osteoporosis was 51.43%(18/35). Conclusions 1.Life style, habit, emotion, and childbearing history were the important factors of POF. Good diet habits, no smoking and limited drinking, losing weight cautiously, keeping well mood, taking more exercises, avoiding artifical aboration , would reduce the incidence of POF. 2. Avoiding or reducing environmental pollution , avoiding infection and other harmful factors, using medicine carefully,would be the effective factors to maintain the ovarian functions.3.The high incidence rate of osteoporosis in POF ( 51.43%) indicated that prevention and treatment osteoporosis in POF is very important.