The Effects Of Fufangbiejiarangan Regulating Extracellular Matrix Degradation Balance On Renal Interstitial Fibrosis In Experimental Research

Renal tubulointerstitial fibrosis is the final common result of a variety of progressive injuries leading to end-stage chronic renal failure(CRF). The extent of renal interstitial fibrosis indicates the damaged degree of the renal function and determines the prognosis of the chronic nephropathic patients. So the genetic and developmental mechanism of renal tubulointerstitial fibrosis is now catching the attention of more and more domestic and overseas researchers.Renal tubulointerstitial fibrosis is characterized by the accumulation and deposition of ECM protein including collagen I ,II,III and IV, meanwhile lots of interstitial cells get proliferated increasingly. These lead to the atrophy or desolating of renal tubules and peripheral capillaries, also induce the progressive loss of integrated nephron, the result of which is the continuous decreasing of glomerular filtration rate and in the last getting into renal failure.Renal tubulointerstitial fibrosis derive from a slow dynamic process, which involes the complicated interaction of cells, cytokines and ECM. In the past, the major emphasis has been on control of the synthesis of ECM proteins in renal tubulointerstitial fibrosis, but it can't elucidate the complete pathological process distinctly. For the past few years, more and more researchers turn focal point to the degradation mechanism of ECM. Among the enzyme systems involed ECM degradation, MMPs(matrix metalloproteinase) system is the most important one.MMPs is one group of Zn²⁺ -depended incisive enzymes which have syngeneic structure and function, and TIMPs(tissue inhibitors to metalloproteinases) pairs up with MMPs as their special endogenetic tissue inhibitors, the most pivotal pair of which is MMP-9/TIMP-1 in the renal fibrogenesis. MMP-9 also can be called as gelatinase ,which can degradate most of denaturational collagen, basilemma including collagen IV and collagen V. Many factors can regulate the expression of MMP-9, some can level up the expression of MMP-9 such as IL1-α,β TNF-a bFGF PDGF NO, some can level down its expression such as γ-IFN, retinoic acid and glucocorticoids. Some growth factors can up-regulate the expression of MMPs through inducing the expression of proto-oncogene as c-fos and c-jun. Many growth factors and cytokines that can regulate the expression of MMPs also can modulate the production of TIMPs. All of MMPs are secreted as form of proenzyme, whose activation is made by...