Arrived When The Soup Together The Xiaoxianxiong Tang Cut Side Of Experimental Pulmonary Interstitial Fibrosis Serum Laminin Protein And Serum Type ¢ó Collagen Affect Experimental Research

[Objective] To approach the effects of Didang and Xiaoxianxiongtang Modified Formula on mucoprotein in stratum medium of blood-serum and the III-type collagen level in experimental Rats with fibrosis disease in lung interstitial tissue and curative effect and mechanism of action of this decoction treated the disease of fibrosis in lung interstitial tissue.[Methods] 40 male Wistar rats were randomly divided into 4 groups, that is pseudo-operation group, model control group ,control group of traditional Chinese drug(TCD) and control group of Prednisone(P). Every group has 10 rats. Acid hydroc bleocin was dripped disposably into trachea of every group rats except pseudo-operation group ,and Sodium Chloride with same volume as Acid hydroc bleocin was dripped disposably into trachea of pseudo-operation group. 24 hours after operation , the rats of TCD was lavaged with Didang and Xiaoxianxiongtang Modified Formula, and the rats of P was lavaged with Prednisone physiological saline solution; the rats of pseudo-operation group and model control group was lavaged with Sodium Chloride with same volume as TCD and P. 28 days after operation, the rats was executed. And then contents of mucoprotein in stratum medium of blood-serum and the III-type collagen was detected.[Results] Didang and Xiaoxianxiongtang Modified Formula could cut down contents of mucoprotein in stratum medium of blood-serum and the III-type collagen in experimental Rats with fibrosis disease in lung interstitial tissue, and extenuated fibro-accrementition in lung interstitial tissue. [Conclusion] Didang and Xiaoxianxiongtang Modified Formula has the function of treated fibrosis disease in lung interstitial tissue probably by cutting down contents of extracellular matrix in experimental Rats with fibrosis disease in lung interstitial tissue.