Breast Cancer Taxane Drug Resistance And Gst¦Ð Related Research

Breast cancer is the most common malignant disease of women.In female,the mortality of breast cancer is the highest one. Pathologic response of breast cancer to chemotherapy has a great prognostic importance. Glutathione-S-transferases (GSTs) are a family of Phase II detoxification enzymes that catalyse the conjugation of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds. They might detoxify chemotherapeutic drugs within the cancer cells, thus contributing to chemotherapy resistance.The pi isoenzyme of GSTs seems to be of great relevance.Thus, we hypothesized that GSTπ expression in cancer can be a prognostic indicator of drug resistance. The trying for searching GSTπ and the drug resistance that has predictive value for antitumor drugs is a hot topic in tumor-pharmacology for a long time.Taxans, which is a kind of chemo-agent often administered systemiclly, play an important role in the treatment of this disease, whether in adjuvant setting for proventing recurrence or metastatsis after resection or rescue setting for treatment of advanced disease. The aim of this study is to observe the corelation of GSTπ and the drug resistance of taxans. In order to verify the clinical results and to provide reasonable evidence-based information for the medical treatment of breast cancer, related basic research in vitro is also conducted in cell level. Our study includes three parts.First part: As an important member of phase II enzymes, many studies have reported the presence of GST π in tumors. In order to further characterize the role of...