Experimental Study Of Ciprofloxacin Hydrochloride Floating Sustained Release Tablets

The dissatisfactory bioavailability of orally dosed ciprofloxacin hydrocloride (49%-70%), a water soluble drug, is due to the presence of first-pass effects and a biological window comprised of the upper gastrointestinal tract (UGT). The purpose of the present study was to develop and optimize in vitro a hydrodynamically balanced system (HBS) for ciprofloxacin hydrocloride with increased gastric residence time(GRT) and to evaluate the in vitro and in vivo performance of the dosage form.On basis of pre-experiments and pharmaceutical pre-formulation studies, A five-factor four-level orthogonal design was employed for formulation development, and the capability of drug floating was used as the screening index. A single-factor study of formulation and technology was also employed for drug floating and releasing mechanism, and a novel buoyancy measuring system was designed to evaluate in vitro floating parameters. The HPMC floating mechanism shown, its density increased when swelled in the medium, which is disadvantage to floating. The drug releasing mechanism shown, the sustained-release tablet erose at first and diffuse at last, which depend on the time of HPMC forming the gel. Also some beneficial attempt was made on other adapt exipient in our study.Preparation influence factor test approved, it is mainly sensitivity to...