The Application Of Magnetic Resonance Imaging Study Of Schizophrenia

Magnetic resonance imaging is a non-invasive technique to accurately study the human brain and is also important for medical diagnosis. Research on human brain function is one of the most challenge works which would accelerate the development of neuroscience and clinic diagnosis. Functional magnetic resonance imaging is a new technique to research the brain activity in vivo. Recently, functional as well as anatomical magnetic resonance imaging has been widely used in investigations of neurological and psychiatric disorders. In our study, MRI was mainly used to investigate the radiological manifestation of Schizophrenia.In order to optimize the radiofrequency-coil selection in a 3 Tesla MR scanner, we compared the image quality between a birdcadge head coil and an 8-channel phased array coil by using a classic finger-taping task. The statistic parameter mapping results demonstrated that birdcadge head coil was more sensitive and stable than 8-channel head coil in detecting brain cortex activation during task-related fMRI processing.The concept of"Default Mode"is a marker of brain connectivity research in resting-state. It was defined as a cohort of spatially remote brain regions which showed the same pattern of spontaneous blood oxygenation level dependent activation during the resting state. In this study, a method combined low frequency fluctuation theory and general linear model was adopted to investigate the"Default Mode"of normal people, schizophrenia patients and epilepsy patients. The results suggested that in using sufficient temporal-spatial information of functional magnetic resonance imaging data, this method could stably detect the brain area with spontaneous low frequency fluctuation in normal group. The schizophrenia patients group showed significant diminished and disappeared brain areas of blood oxygenation level dependent signal fluctuation during the resting state. In the study of epilepsy, patients were separated into two subgroups: generalized seizure and partial seizure, and deactivation of the precuneus / post cingulate cortex areas existed only in patients with generalized seizure during resting state. It can be a marker for patients with generalized seizure. These results may help us in understanding certain clinical symptoms and help even further in medication.In this study, we used an optimized-voxel based morphometry method to investigate the gray matter deficits of Schizophrenia patients. It had been studied through sex, family history and structure asymmetry on treatment na?ve patients. All results showed significant discrepancy between patients group and their normal controls. It was suggested that the Schizophrenia was suffered from great gray matter deficits, which was significantly impacted by sex, family history and so on.