The Protective Effect Of Focal Cerebral Ischemia In Experimental Studies Of Brain Network Macaroni

Objective To explore the protective effect of Naoluotong Powder (NP) on the focal cerebral ischemia injury model of rat. To Verify the effect of ZP on ischemic stroke protection.Methods Focal cerebral ischemia modcl was made via the thread-occluding method to explore the protective effects of NP on the score of neurological deficits,the rate of cerebral infarction and histomorphology of cerebral ischemia in rats. The effects of ZP on the haemodynamics,cerebral blood flow and cerebral vascular resistance in the anaesthetized dog were investigated in the 8-channel physiology recorder.The ADP-induced platelet aggregation was respectively measured by LBY-NJ-platelet aggregation apparatus,The intensity of platelet aggregation and the maximal aggregation intensity in the time of 60s. 180s, 300s were Determined, The thrombus length, wet weight and dry weight were determined by the extracorporeall XSN-12 type thrombopoiesis instrument. The whole blood viscosity at high shear rate. middle shear rate and low shear rate. hematocrit and blood plasma viscosity were checked in the animal model which was made by equal hypo of Adrenalin (Adr) 0.08 ml/100g. 5 minutes bring about rat blood within rat infusion ice water stagnating. PT and APTT were Determined by MC-4000 type semiautomatic blood curdle analytical instrument. The time of mouse entire brain death was recoderd by the time recording.Results The results of research are indicate that NP was perthsed to the stomach of rats by 1.6, 0.8g/kg respectively,which could distinctly improve the score of neurological deficits of cerebral ischemia rats(P<0.05),reduce the rates of cerebral infarction rats and the level of cerebral ischemia injury,It is able to improve the cerebral tissue of pathological. It also increase the anaesthetized dog's cerebral blood flow (P<0.05,P<0.01,P<0.001)and reduce cerebral vascular resistance(P<0.05,P<0.01 ).The 1.6 g/kg. 0.8 g/kg. 0.4 g/kg three species dosage without exception have inhibitory action to model rat blood plasma blood platelet aggregation(P<0.05). The 1.6 g/kg group has an obviously effect to reduce the whole blood viscosity at high shear rate,middle shear rate,low shear rate and hematocrit compared with model group(P<0.05,P<0.01,P<0.O01). Every dosages of NP have the obvious lessening effect to the thrombus length, wet weight; dry weight(P<0.05,P<0.01,P<0.O01).It could increase the time of the mouse takes a breath(P