| Objectives:To detective the effective methods of protection the optic nerve through observe the optic functions by acuopint injection the Ligustrazine after glaucoma surgery, provide a scientific basis of Ligustrazine point injection for the treatment of optic nerve impairment which caused by glaucoma.Methods:45 patients (60 eyes) which is glaucoma, whose intraocular pressure controlled after anti-glaucoma operation, all cases were randomly divided into two groups: treatment group (23cases, 30 eyes) and control group (22 cases 30 eyes). All cases in treatment group had three points injection use the ligustrazine(40mg/2ml) per day, the points include temple, qiuhou, chengqi, fengchi, hegu, ganshu, shenshu, pishu, zusanli, sanyinjiao, guangming, the qiuhou point give the injection interval 5 days, if patients had only one eye was involved, had another point injection. We use the injection needles on the 5th inject 1ml ligustrazine in each one point per day, therapy consecutive 10 days and have 5 days rest called a course of treatment, a total of eight treatment regimen together four months. Control group with no treatment, regular follow-up observation. All patients didn't use any ocular and systemic drugs. Before observation and after observation, all cases had a optic vision check, vision field examination and retinal nerve fiber layer thickness (RNFLT) check by ophthalmology experts. of 30 eyes was 16.67% and the control group total effective rate of 30 eyes was 10.0%. There had no statistic difference between treatment group and control group (X~2=0.144, p＞0.05). 2. The visual field comparison between two groups: In the treatment group, the MS and MD before-treatment was 14.07±3.53dB and 16.61±2.60dB, the MS and MD after treatment was 18.32±3.52dB and 12.21±1.98dB. In the control group, the MS and MD before treatment was 14.57±3.85dB and 15.46±1.96dB, the MS and MD after treatment was 15.30±3.67dB and 15.05±1.89dB. There had no statistic difference between two groups before observation (t=0.52, 1.93 p＞0.05). The treatment group have statistic differences compared with before therapy (t=5.03, 4.52 p＜0.05). The control group have no statistic differences compared with before therapy (t=0.68, 0.96p＞0.05). There had statistic difference between two groups after observation (t=3.74, 4.03 p＜0.05). 3. The comparison of RNFL: RNFL of the treatment group was 74.47±12.79,73.17±13.73um at therapy around. RNFL of the control group was74.73±13.72,72.60±12.09um at observation around there had no statistic difference between two groups (t=0.3796, 0.639, p＞0.05) or in each group(t=0.16970.639,, p＞0.05) at observation around. 4 The therapy didn't cause any side effect.Conclusions:The method of point injection Ligustrazine can protect the visual functions because it can improve the light sensitivity in glaucoma patients with postoperative whose IOP were controlled and can decrease the average defect in visual field, it also can stabilize the RNFL and active the functions of retinal ganglion cells. The therapy is safe and effective. |
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