Qi Quality Theory And Their Peripheral Blood Gene Differences

With the enlargement of social pressure,the spirit factor in the morbidity and the treatment is payed more and more attention,the constitution relates to the abnormal spirit. This topic mainly carries on the related collection and regarding the mRNA differential demonstration experimental study between the circumference blood the constitution of qi stagnation and non-qi stagnation,focusing on identifying the gene of qi stagnation constitution.First, clear the constitution of qi stagnation related to the concept and connotation. Reorganizate the ancient literature to explain the association and difference among qi stagnation, qi stagnation pathogenesis, stagnation syndrome, YANG stagnation, the constitution of qi stagnation.From《huang di nei jing》,sum up the related recognition. Considering the cause, mechanisms, criterion standard, invasion tendency and clinical application, obviate correlated disease,such as stagnation syndrome, globus hysteritis, viscera-rest lessness, lily disease, vesania, flatulent colic, cardiac spasm, anandria, irregular menses and so on.Second, the mRNA differential demonstration experimental study between the circumference blood the constitution of qi stagnation and the constitution of non-qi stagnation.We chose 3 the constitution of qi stagnation and 2 the constitution of non-qi stagnation.Through the experimental study,we discovered that its expression has the following characteristic: In the group qi stagnation and the non- qi stagnation, the majority of gene expression is the same, a part of gene expression did not exist in non-qi stagnation, but the high expression did in qi stagnation. After the NCBI US country gene bank retrieval, this part of genes has six known genes: being located at person chromosome 1q32 plexin A2, 1q11 notch 2 preproprotin, 17q25 nuclear prelamin A, 1q24 T-cell receptor Zeta chain, 14q13 neuronal PAS domain protein 3, 5p12 S-phase kinase-associated protein 2. Plexin A2 and neuronal PAS domain protein 3 are the correlated gene of dementia praecox. Nuclear prelamin A has related with some genetic disease. T-cell receptor Zeta chain has related with allergic inflammation. S-phase kinase-associated protein 2 play an important role in tumorous advancement.It means whether qi stagnation constitution easily lead to muscular dystrophy, heart block , premature ageing ,kinds of Inflammatory reaction and malignant or not? The study of the qi stagnation need go on.