| Objective to observe the clinical curative effect,the onset time and adverse effect of Qingbitang combined with minor dosage Methotrexate(MTX) in treating rheumatoid arthritis(RA)and discuss its mechanism.Meathods:1 55 cases coming from the rheumatoid department of The NO1.Hospital OF Wuhan City.All the patients are in acute or acute stage whose dialectical were hot and humid sub-type resistance Tongxinluo.2 55 patients were randomly divided into two groups of 30 cases and 25 cases of the control group.Two groups of patients in gender,age,disease, and related factors,such as grading have no significant difference(P＞0.05),and they are comparable.3 Observer Group for Bi-and small-dose methotrexate treatment.Tang Bi-wood thieves from grass 50 g,Hanshui Dan 30g,Ukraine slightly snake 20 g of drugs,such as shamisen,and a weekly oral methotrexate(MTX) 7.5mg,with folic acid tablets weekly 5 mg(clothes MTX 24 hours after taking)treatment.4 Control group:once a week to give oral MTX 10mg,with folic acid tablets weekly 10mg(clothes MTX 24 hours after taking)treatment.A course of treatment for one month,three months after assessing efficacy.5 Observation of drugs before and after the following indicators:joint tenderness,joint swelling,Chert Jiang time and joint function,and other clinical symptoms and signs integral;6 Ritchie joint before and after the treatment index.7 Before and after the treatment of blood biochemical indicators: erythrocyte sedimentation rate(ESR),C-reactive protein(CRP), rheumatoid factor(RF),blood,liver function,kidney function and drug toxicity.Results:1 Observer Group effective 27 cases,three cases invalid,the rate was 90 percent;effective control group of 16 cases,nine cases invalid,the rate was 64 percent.Observer Group efficient compared with the control group are significant differences(0.01＜P＜0.05),the observation group than the control group;2 The two groups before treatment in patients with joint pain,swelling, function,Chen Jiang,and other symptoms and signs integral and Ritchie joint index there was no significant difference(P＞0.05).3 Two groups of patients before treatment blood biochemical indicators such as:blood,liver function,ESR,CRP,ESR,RF,and so there was no significant difference(P＞0.05).4 After the two groups of patients with the treatment of joint pain, swelling,function,Chen Jiang,and other symptoms and signs integral index,such as joint and Ritchie have different levels of change(P＜0.01; P＜0.05),the degree of change is better than the control group Group(P＜0.01);5 At the same time the two groups can reduce the ESR,CRP,ESR,and other laboratory indicators(p＜0.05;P＜0.01),the observation group also better than the control group(P＜0.01);6 Before and after treatment in the control group RF indicators did not change significantly(P＞0.05),the RF group were significantly different (P＜0.01);7 The X-ray observation group some improvement,but not statistically significant(P＞0.05),the control group of radiology has not changed.8 Observer Group of the side effects of drugs significantly less than the control group.Conclusion:1 Bi-obvious anti-inflammatory and analgesic effect.2 Bi-and low-dose methotrexate in the treatment of acute rheumatoid arthritis or acute stage can significantly shorten the course,good clinical symptoms in patients with ease.3 Bi-and low-dose methotrexate in the treatment of RA can significantly reduce the inflammation and indicators of rheumatoid factor.4 The treatment of RA can reduce the amount of MTX,reducing the side effects caused by MTX,but also improve efficacy.5 Bi-and low-dose MTX treatment of RA hot and humid Tongxinluo-effective way to improve syndrome,without obvious side effects,safe,effective and worth promoting... |
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