Compound Naodesheng The Flavonoid Composition And Quality Of Analysis

Compound Prescription NaoDeSheng consists of five medicines which are RADIX NOTOGINSENG,RHIZOMA CHUANXIONG,Safflower PUERARAE and Hawthorn Fruit, accepted in China pharmacopoeia in 2005 edition..it shows notable curative effect in treatment with cerebral arteriosclerosis, Ischemic Stroke and sequelae of cerebral hemorrhage. But owning to its traditional Production Preparation Process, large dose,poor stability,absorption and bad control of quality exist.The article carried the realated research on the material basis of Compound Prescription NaoDeSheng and Quality assessment systerm.,so as to provide a good foudation to Secondary Development of Prescription NaoDeSheng.The purification handicraft has carried out the method adopt the orthogonality experiment on NaoDeSheng flavonid drawing giving selections preferential treatment studying, has ascertained Safflower PUERARAE and Hawthorn Fruit flavonid alcohol back-flow extracting and the D-101 macroporous resin purification technological parameter.The parameter above we got is proved to be stability and reliable.The content of total flavonoids in extract is above 78.1%.So it provide the basis for improving the traditional production preparation process.Has adopt menstruum to follow sum chromatography having been in progress to NaoDeSheng total flavonid extracting separation studying , has got 5 monomer components out of,they are kaempferol,quercetin,puerarin,3' -melhoxypuerarin and rutin. This several kinds compound are that the root of Safflower and Hawthorn berry flavonid extract.Puerarin and hydroxysafflor yellow A has be examined with HPLC analysis method . The analysis method was well repeated and good credibility.Our research can effectively control the quality of total flavones extractive of NaoDeSheng.According to country medicines and chemical reagents food without exception superintending the relevance request that the administration bureau promulgates, the fingerprint on total flavones in total flavones extractive of NaoDeSheng was studied by HPLC,with result that 23 peaks were common respectively.The method is stable ,well repeated and may offer abundant scientific basis of the quality evaluation of total flavones extractive of NaoDeSheng.