Study Of The Efficacy Of The Brain And Heart Capsule Material Base And Pharmacodynamics

Objective: Stroke is a kind of clinical common disease .And its onset is often leaves behind much aftereffect in different degree. So it is one of the disease that endanger the health of old people.Naoxinshu capsule is clinical experience. But to be developed into new preparation. However, some limitations are still in existence. The medicinal substances, preparation technics,quality-control methods and pharmacological effects are still need to be researched deeply. Therefore, this project is going to find medicinal substances of Naoxinshu in treating stroke and study the pharmacological effects of it in order to provide the material for the new medicine reported.Methods: According to the active ingredients of medicines, and the actual cost of production and the post-mortem to determine the dosage form preparation, extraction method. We use orthogonal experimental method to a paste rate and the effective components in the index to determine the optimum extraction process. In the process of stability in the post-test products, study the effect of the preparation of this capsule.In pharmacological effect this study its effect on the Naoxinshu Capsules main pharmacological effects were observed: Naoxinshu capsule on the rat brain model of ischemic injury, cerebral blood flow to the animals cerebral vascular resistance and the impact of the Animal thrombus formation of the rat platelet aggregation, plasma prothrombin time (PT) and plasma prothrombin time (TT) the impact of blood stasis of blood rheology animal model, as well as the impact on the aggregation of red blood cells impact.Results and Conclusions:Naoxinshu Capsule for the Preparation of the final: Hongshen, Shuizhi crushed into powder.Qingpi six times in 70% ethanol to extract three times, followed by 2,2,1 hours, the merger extract, filter, and the filtrate decompression recovery ethanol concentration to the relative density 1.30-1.35 (50℃) thick Plaster, vacuum drying (60℃), crushed into powder. Bingpian grinds into powder and matches with above powder grinds.blending, packaging, made from 1000, that is. Efficacy experiment through the preparation of this animal model of cerebral ischemia improved to a certain extent, and increase cerebral blood flow, inhibiting thrombin function, blood stasis animal model animal blood viscosity increased significantly change the role of regulation and plastic injection the original protein - adrenaline mixture erythrocyte aggregation induced significantly inhibited.