Fundus Fluorescein Angiography Role In Staging And Treatment Of Retinal Vein Occlusion Tcm

Objective:To standardize Traditional Chinese Medicine (TCM) pattern of retinal vein occlusion(RVO) by correlating TCM pattern and fundus fluorescein angiography(FFA).then treated RVO according to the results of TCM pattern, to evaluate efficacy of TCM pattern treatment and to find a sort of regular treatment method which would be used widely in future for bleeding ocular fundus diseases in TCM.Methods:92 cases (92 eyes), who were divided into three stages viz. bleeding stage 29 cases(29 eyes ),gore stage 35 cases (35eyes) and dead-dry blood stage28 cases(28eyes) were respectively treated with the home-made Chinese medicine (Zhixuekoufuye. Yanxuekangkoufuye,Yishipian and Huayusanjiepian)in trial group. 44 cases(44 eyes) were treated with Chinese patient medicine capsule Fufangxueshuantong in contral group. The clinical effect were observed in two groups principally by FFA.Results:(1) The trial group and contral group both could improve the symptoms, the trial group wasstatistically remarkably superior to the contral group.(2) the trial group could increase visual acuity, promote the absorption of retinal hemorrhage.lessen retinal vessel leakage, relieve macular edema, while the contral group could not. the trial group was statistically superior to the contral group.(3) the trial group statistically and the contral group had the same effect in relieving theextension of retinal vessel.(4) the trial group and contral group neither could prevent ischemic non-perfusion areas. Therewas no statistically significance between two groups.(5) the trial group and contral group both lessen blood viscosity, the trial group statisticallysuperior to the contral group when the shear rate are 200 L/s and 5L/S .(6) It is more probable that gore stage and dead-dry blood stage have major probability aboutthe appearance of microaneurysm and ischemic non-perfusion areas in retina than in bleeding stage , while it is equivalent between gore stage and dead-dry blood stage.Importantly the probability that microaneurysm and ischemic non-perfusion areas appearwas equivalent in gore stage and dead -dry blood stage .Conclusion: this study shows the therapeutic effect is more predominant in TCM pattern treatment than in non-TCM pattern treatment as follows:(1) It could improve the symptoms and increase vision acuity.(2) It could improve function of blood-retinal barrier, decrease vessel permeability, promote theabsorption of retinal hemorrhage, lessen retinal vessel leakage, relieve macular edema.(3) It could improve blood circulation , lessen blood viscosity.(4) Microaneurysm and ischemic nonperfusion areas are probably the characteristic of FFA ingore stage and dead-dry blood stage. Microaneurysm is probably the characteristic that prognosticates the appearance of ischemic nonperfusion areas soon.