| ObjectiveDiscussed clinical characteristics and TCM-based distribution of children with Tourette syndrome,summarized rules of prescriptions which were used by Professor Wang Sumei,in order to provide the clinical foundation for Liujunzi Tang and Xiexing Wan.Evaluated the behavior of iminodipropionitrile (IDPN)-induced mouse model of Tourette syndrome and observed the impact of changes in behavior by herbal medicine,so as to provide experimental basis for clinic.MethodsInvestigated parents and children with TS using self-made "Tourette syndrome survey",including all the symptoms which were needed for TCM diagnosis.Set up TS animal model by intraperitoneal injection of IDPN and treated with Chinese medicine or Tiapridal.Tourette syndrome mice were evaluated by autonomic activities,head nutation and climbing time,and observated behavioral changes each.Results1.Tourette syndrome and genderThere were 322 boys and 93 girls in 415 cases of children with Tourette syndrome.Boys outnumbered girls in the ratio of 3.46 to 1,and this was consistent with previous literature reports.2.Tourette syndrome and age2.1 Age of onsetIn 415 cases of children with Tourette syndrome which were collected according to the standard,the minimum onset age was 2 years old.The maximum was 16 and average age was(7.06±2.53).2 cases were in 2～3~- year-old period (0.48%).188 cases were 3～7~- year-old(45.30%).7～13~- year-old children were 215 cases(51.81%).13～16~- were 10 cases(2.41%).The highest incidence was onset when one was school age from 7 to 13.2.2 Age of visitingIn this group,the visiting age distribution is 4～7~- year-old of 79 cases (19.04%),7～13~- year-old of 263 cases(63.37%),13～18~- year-old of 73 cases (17.59%),and the average age is(9.56±3.14) years old. 3.Tourette syndrome and courseThe longest duration of children in the group was 12 years and the shortest less than one year.The average duration was(2.51±2.37) years.It can be seen that Tourette Syndrome lasted for long period and gradually attracted people' s attention.4.Tourette syndrome and TCM syndrome distributionThe survey showed that splenic asthenia and liver domination was the most frequent TCM syndrome for Tourette syndrome.The mainly frequency was 172,which constitute more than 41.45%.It followed by spleen asthenia and poly-sputum, frequency of occurrence for 125,which constitute more than 30.12%.Next syndrome was stagnated QI transforming into fire,which happened in 109 cases and constituted more than 26.27%.Stirring of wind due to deficiency of YIN was the least,which only occurred on 9 chileren and constituted 2.17%.The investigator analyzed the relationship between gender and TCM syndrome,visiting age and TCM syndrome,found that boys and girls,different ages all had the same order in TCM syndrome.5.Rules of Chinese medicine for Tourette syndromeIn the observation of more than 640 prescriptions,there were a total of 153 kinds of Chinese herbs and 31 kinds occurred more than 100 times.The most use of frequency were Fangfeng,used 469 times,and followed by Dilong,418 times, Mugua,381times,Shenjincao,378 times,Gujingcao,318 times,Juhua,305 times, Jingjie,303 times,Gegen,298 times,Chaihu,295 times,Gouteng,283times and so on.The herbs in Liujunzi Tang and Xieqing Wan occurred frequently,and main were all used more than 150 times.6.Behavior evaluation of the mouse model of Tourette syndromeSet up TS animal model by intraperitoneal injection of IDPN and evaluated by autonomic activities,head nutation and climbing time.The model had good quality in the performance of validity,easy operation,high rate for copy and maintenance of the symptoms for a long time.This method provided a model foundation for further research of Tourette syndrome.7.Behavior changes of the TS model mice with compound Chinese medicineUsing the IDPN-induced animal model,compared changes of behavior caused by the Chinese medicine and Tiapridal.The Chinese medicine team and the Tiapridal team both have less action than the model.From a long time,Chinese medicine has better effect than Tiapridal.Conclusion1.Tourette syndrome has the highest incidence in school-age 7 to 13~- years old. 2.Incidence in boys is higher than girls.3.Splenic asthenia and liver domination was the most frequent TCM syndrome for rourette syndrome.It followed by spleen asthenia and poly-sputum,stagnated QI transforming into fire and stirring of wind due to deficiency of YIN.According to invigorating the spleen and purging the green,we use Liujunzi Tang and Xieqing Wan for the treatment of multiple tic disorder in children.4.In the observation of more than 640 prescriptions,there were a total of 153 kinds of Chinese herbs and 31 kinds occurred more than 100 times.The most use of frequency were Fangfeng,used 469 times,and followed by Dilong,418 times, Mugua,381 times,Shenjincao,378 times,Gujingcao,318 times,Juhua,305 times, Jingjie,303 times,Gegen,298 times,Chaihu,295 times,Gouteng,283 times and so on.The herbs in Liujunzi Tang and Xieqing Wan occurred frequently,and main were all used more than 150 times.5.IDPN-induced Tourette syndrome mouse model simulates parts of the human Tourette's syndrome symptoms,and is a good animal model of Tourette syndrome.6.Liujunzi Tang and Xieqing Wan has a good effect on the tics of the IDPN-induced animal model.From a long time,Chinese medicine is better than Tiapridal. |
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