Research And Development Of Gout Pain Relief Capsules

The best Preparation Process of the Gout pain Capsules was determined through the experimental study,and established the technical standards for Quality Control in order to guarantee the safety and effective of clinical medication.According to the function of the Prescription and the properties of medical Components the Production Process was studied,Use Single-factor and Multi-factor experimental methods respectively,filter the best extraction process,and through the research of preparation process,and the scientific and rational preparation process were got,to further confirm the technical parameters through the Pilot Study,finally steady preparation,good reproduction quality,short production period preparation process were got,and it meet the Appendix of First Division that belong to the 2005 version "Chinese Pharmacopoeia".To use the TLC to Identified all the herbs in the preparation,the result is that the tested products with the control by medicine or reference substance in the corresponding position with the same color of the dot,and no negative samples interference,so that the Specific and reproducible TLC above were Included in the Quality Standards of Gout pain Capsules.To use the HPLC to determined the contents of loganin in cornel,and te methodological study was used,the result is that to use 18 alkyl silane bonded silica as filler,acetonitrile-water-phosphoric acid(14:86:0.1) as the mobile phase,detection at 240 nm,Loganin glycosides reference substance in 0.0636～1.2720 g with the integral value of peak area was a good linear relationship(r=0.9996),the average recovery rate was 97.33%,RSD=2.04%(n=5),according to the determination values of 10 samples,determine the content limit,measured cornel by the content of Loganin glycosides(C₁₇H₂₆O₁₀),every one should be not less than 0.12mg.Conclusion is that this method is simple,specific and reproducible,and can be used as the preparation of quality control.