Qi And Yin And Treatment Of Chronic Nephritis Clinical Studies

Objective:To research primarily the effectivess and safety of profit Qi raises the Yin method in treat chronic glomerulonephrit for Qiyinliangxu syndrome.Methods:A double blind,double dummy and randomized controlled method was adopted.A total of 48 patients were randomized to the treatment group(Shenkang capsule,2 capsules, twice a day) and the control group(Shenyankang capsule,2 capsules,twice a day).The therapeutic course for both groups was 8 weeks.Results:All the results were analyzed on the basis of full analysis sets(FAS) and per-protocol-population(PP).For effect of chronic glomerulonephrit is in the treatment group, the clinical control rates were 9.1%(2/22) with FAS analysis and 11.1%(2/18) with PP analysis;good mi provement rates were 27.3%(6/22) with FAS analysis and 33.3%(6/18) with PP analysis;the total effective rates were 59.1%(13/22) and 72.2%(13/18).In the control group,the clinical control rates were 8.3%(2/24) with FAS analysis and 10.0%(2/20) with PP analysis respectively;the good mi provement rates were 4.2%(1/24) with FAS analysis and 5.0%(1/20) with PP analysis respectively;the total effective rates were 45.8%(11/24) with FAS analysis and 55.0%(11/20) with PP analysis.There was no statistical difference between the two groups(P＞0.05).For Qiyinliangxu syndrome mi provement in the treatment group,the clinical control rate and good mi provement rate were 22.7%(5/22) with FAS analysis and 31.3%(5/16) with PP analysis respectively;the total effective rates were 59.1%(13/22) with FAS analysis and 81.3%(13/16) with PP analysis respectively;In the control group,the clinical control rate and good mi provement rate were 20.8%(5/24) with FAS analysis and 26.3%(5/19) with PP analysis respectively;the total effective rates were 45.8%(11/24) with FAS analysis and 57.9%(11/19) with PP analysis respectively.The results showed no statistical difference between the two groups(P＞0.05).No adverse effects were found.Conclusions:No statistical difference was detected between Shengkang capsule and Shenyan capsule groups.No obvious toxic adverse effects were found.