Thrombosis Model And Improved Photochemical Method Xiaoshuan Meridians Soup Thrombosis

Objective: To establish a basis for the photochemical reaction to the improvement of animal thrombosis of the photochemical model has been set up based on the improved photochemical animal model to study Consumers thrombosis suppository Tongluo soup on the improvement of the photochemical animal model of thrombosis; the Clinical treatment of thrombotic diseases prescription Consumers suppository Tongluo soup prescription optimization of the structure. Methods: mice via the tail vein injection to Bangladesh red, mice ears flattened into biological function experimental system and micro-Cycle Observing System under the microscope, with a wavelength of 490 nm light cold blood vessel targets irradiated mice ear, observation and Records mouse ear target vascular blood flow, blood flow velocity at different time points and the complete cessation of blood flow evaluation of the time of thrombosis of the indicators; mice by gavage month after administration, with an improved photochemical Law making model mice, and compared the model group, Consumers suppository Tongluo soup aspirin group and between groups mouse ear at different time points of vascular blood flow velocity changes in blood flow stopped, the differences in platelet count Consumers evaluation as a suppository Tongluo soup on the improvement of the photochemical animal model of thrombosis indicators improved use of the uniform design, in mice at different time points to the blood flow velocity changes in blood flow to stop time, the changes in platelet count pharmacodynamics of indicators To evaluate indicators, the best compatibility and best prescription dose ratio of comparative study. Results: Bangladesh Red Group in the cold light exposure for five minutes, the mice ear blood flow speed has slowed down, exposure to 25 minutes, the complete cessation of blood flow; Consumers suppository Tongluo soup cold light irradiation Group 5 10 minutes later, blood flow speed has slowed down, exposure to 25 minutes, the high-dose group, in the dose group did not stop blood flow, low-dose group of the complete cessation of blood flow, as the dose increases, the aggregation of platelet inhibition Enhance the role; uniform design that the Tongluo Consumers bolt-best compatibility and the best dose ratio of the theoretical value, experience and certification confirmed that the extract of 10 (Hirudo (3 g), Radix Angelicae (27), Pheretima ( 24), Rhizoma Chuanxiong (21), Radix Achyranthis Bidentatae(15), Rhizoma Acori Tatarinowii(9)) and theoretical 4 (Hirudo (3 g), Radix Angelicae(30 g), Pheretima (30 g), Rhizoma Chuanxiong (25 g), Radix Achyranthis Bidentatae (20 g) ), the theory group Yaowei less, it recommended for clinical use, and after the development of new drugs. Conclusion: 490 nm cold light irradiation has been injected mice ear Bangladesh red blood vessels, can cause blood vessels in mice ear stop, a photochemical reaction can be established based on the animal model of thrombosis; Consumers suppository Tongluo soup on the improvement of the photochemical Animal thrombosis model is certainly the impact of this experimental research methods and analysis will be demolished to study the best dose ratio combining the optimization of a practical application of the prescription.