The Forsythia Volatile Oil Fractions Pharmacodynamic And Self-emulsifying Drug Delivery Systems

Forsythia is a dry fruit of Oleaceae Forsythia plants. It is bitter, non-toxic and slightly cold. Forsythia is clearing away heat and toxic drug commonly used in Chinese medicine,it has always been regarded as an important drug for the treatment of traumatic. Modern pharmacological Studies Show that Forsythia has functions of antibacterium, antivirus, anti-inflammation,antipyretic,analgesic diuresis etc. This experiment has carried on a series of research mainly aimed at its roles of anti-inflammatory, antipyretic and analgesia.First we use steam distillation to forsythia extrac t forsythia oil. Through the experiment, we found that this method is simple, little energy consumption, extraction of oil is purity and it is easy to separate.This experiment choses vacuum distillation method to separation of the oil. We have separated the oil into seven components according to the different temperature. They are 30℃degrees below, 30℃～40℃, 40℃～60℃, 60℃～85℃, 85℃～95℃, 95℃～120℃and residue. Results show that the vacuum distillation can ont only separate the ingredients of forsythia naphtha, but also some ingredients can be highly enriched.We studied the pharmacological functions of anti-pyretic,anti-inflammatory, detumescence analgesic of the components for different temperature after Forsythia oil had been separated in the vacuum rectifying tower. Results shows that the different components have not only anti-inflammation and analgesic ingredient,but also have inflammatory and pain ingredient,and the efficacy of crude oil is better than single forsythia components. When inflammatory and pain ingredient had been removed, We were re-combination of other components, then we find that the effect of Anti-inflammatory and analgesia are better than the original naphtha's,The experiment shows that the traditional Chinese medicine is a whole of synergy. Efficacy of many components of crude oil produced in the body is better than the sum of function components separately.Because forsythia oil has excitant and strong pungent flavor,patients will be difficult to swallow if we are direct oral. Therefore this paper put the forsythia oil after have been separated and recombined into a new products—Forsythia oil SEDDS, eventually we made it soft capsule and make it easier for use. Irritating and side effects of Forsythia oil SEDDS are reduced greatly.LD50 increased from the 4.95 ml/kg to 7ml/kg . This phenomenon describes the volatile components may be surroundded by milk drops in n the process of SEDDS, It slow releases in the body and reduces the side effects of drugs.