Quinazolinone Derivatives

Quinazoline is a class of alkaloids,exist in some plants,such as Saxifragaceae, Folium etc.They have similar core structure and a wide range of biological activity,mainly in the epidermal growth factor receptor(EGFR) or the tyrosine kinase(EGFR-TK),vascular endothelial growth factor receptor(VEGFR),platelet-derived growth factor receptor (PDGFR),nerve growth factor receptor(NGFR) and other targets and thus play anti-cancer, antibacterial,antiviral and other pharmacological effects.Therefore,the quinazolinone compounds attracted the interest of medicinal researchers.There are a lot of reports of synthesis of quinazolinone.In this dissertation,4(3H) quinazolinone,7-nitro-4(3H) quinazolinone,6-nitro--4(3H) quinazolinone,6-amino-4(3H) quinazolinone,7-amino -4(3H)-quinazolinone,4-oxo-3,4-dihydroquinazolinone-5-carboxylic acid,5-amin o-2-(2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-5-oxopentanoic acid,2,3-bis (hydroxymethyl)-2,3-dihydroquinolin-4(1H)-one[1,3],5-hydroxy-4(3H) quinazolinone, 7-iodoquinazolin-4(3H)-one,7-methyl-4(3H)-quinazolinone,7-bromoquinazolin-4(3H)-one were synthesized by using anthranilic acid,2-amino-5-nitrobenzoic acid,2-amino-4-nitrobenzoic acid,6-nitro--4(3H)-quinazoline-one,o-amino-terephthalic acid, 2-amino-4-hydroxy benzoic acid,2-amino-5-bromo-benzoic acid,2-amino-5-iodine acid,1,4-butynediol,L-glutamine,isatin anhydride,formamide as starting materials and utilizing microwave-assisted synthetic approach.Among them,the 4-oxo-3,4-dihydroquinazoline-5-carboxylic acid,5-amino-2-(2,4-dioxo-1,2-dihydroquinazolin-3 (4H)-yl)-5-oxopentanoic acid,2,3-bis(hydroxymethy 1)-2,3-dihydroquinolin-4(1H)-one [1,3],5-hydroxy-4(3H) quinazoline-one,2-amino-5-bromobenzoic acid, 7-iodoquinazolin-4(3H)-one,7-methyl-4(3H)-quinazolinone,7-bromoquinazolin-4 (3H)-one were not been reported in the literature.