Compound Astragalus Particles Of New Drugs

Objective: this project is the main research work of the party, clinical, overcome traditional into granules treatmentresult decocting, difficult to carry large, save low inconvenience, taste, give full play to the disadvantages such as portable, easy to preserve granule has the advantages of the preparations for the further development and provide certain theoretical basis.Methods:1 for the compound radix particles in the study of preparation technology, the medicine prescribed for water and alcohol respectively by means of orthogonal design, selection, selects the optimal process.2 in the quality control of astragalus and schisandra, established, psoralea corylifolia, containing such TLC identification method, and TLC scanning method for determining the content of mangiferin astragalus armour.3 the compound radix granule stability preliminarily. The stability of the compound radix granules, a preliminary study on the preparation and 40 degrees Celsius temperature, relative humidity of±2 for 75% of±5% of its traits, conditions, moisture, size, the content of mangiferin astragalus armour, dissolution, results show that good stability of compound radix granules.Results and conclusion:1 this experiment chose schisandra and astragalus serie a for the evaluation index, the content of mangiferin through orthogonal design optimization, the extraction conditions for 4 times add alcohol is 80% ethanol refluxing extraction,2 times for 2 hours, water quantity of water decocting six times each time, three times of 2 hours. Extraction solution to concentrate income, some relative density 1.25 excipients in dry and granulating decompression. Through the pilot trial, actually the sample preparation process is safe, reliable and repeatability.3 this experiment established astragalus, schisandra psoralea corylifolia, containing such TLC identification method, the results showed that, comparing with the herbs and standard gc chromatography corresponding control of the same position on the show, and the negative control spots in the corresponding solution position without corresponding TLC spots, Experiments show that the method is simple, sensitive and reliable, strong specificity, reproducible and can be used to identify Chinese.4 this experiment by TLC scanning method for determination of astragalus effective ingredients (astragalus armour, the content of mangiferin) a regression equation of astragalus 4.3153 Y X - 0.2760, r = reached, a linear range for astragalus nucleoside 1.005 ~ 6.030 muong. Experiments show that the method is simple, reliable and sensitive, can achieve the basic purpose of preparation of quality control, is safe and effective.