| Primary lung bronchogenic carcinoma is one kind of the diseases threatening human being health and life gravely. Among which, more than 80% are non-small cell lung cancer (NSCLC).The majority is in the advanced stage and its 5-year survival rate is less than 10%. In recent years, the tumour markers (TM) gets extensive concern as its effect on diagnoses,curative effect and prognostic judgement. However, there are short of objective data on evaluation about curative effect and prognostic judgement but there are much more emphasis on the diagnoses. A total of 212 patients diagnosed with stageⅢB,Ⅳnon-small cell lung cancer were involved in this retrospectively study. To detect correlation of the serum levels of TM with pathologic category,stage,TCM syndromes classification,treatment programs and prognosis. To investigate the effect of TM in diagnoses of lung cancer as well as its significance in treatment and prognosis.Objective:By means of observing correlation of the serum levels of TM with pathologic category,stage in the patients with pathologically proven NSCLC in order to reveal the regularity and practise directive significance in evaluation of curative effect prognostic judgement.Methods:212 NSCLC cases, which all accord with the standard of advanced NSCLC come from Guang'an Men Hospital of China Academy of TCM. We collect patients demology,value of TM,treatment project,short-term efficacy,quality of life and the survival time etc. We use statistical software package to set up database and to deal with the statistics. The difference is considered to have statistical meaning when P≤0.05.Results:1 CEA,Ca125,Ca153 and Ca199 were the most value for the diagnosis of lung adenocarcinoma, SCC,Cyfra211 can be the tumor-markers of squamous cell carcinoma.2 CEA,Ca153 and SCC were concerned with the clinical stage. The value of TM was found to increase with development of the disease.3 The highest level of CEA and Ca199 was found in patients with syndrome of qi and blood stasis, and the lowest was found in patients with syndrome of qi deficiency and phlegm-damp; The major syndrome of adenocarcinoma was qi and blood stasis; In addition, CEA,Ca199 was of great significance in evaluating the prognosis of adenocarcinoma.4 It may suggest a positive response to treatment with NP/NC scheme in adenocarcinoma and squamous cell carcinoma; When compared with adenocarcinoma, there were much more obvious effect on squamous cell carcinoma using GP/GC scheme. 5 The serum level of CEA after treatment was much more significant lower when taking advantages of two kinds of Chinese traditional medicine injector than one kind.6 We found that the higher the serum level of Ca125 was, the shorter TTP especially the possibility that less than 3 months would be.7 The serum level of CEA,Ca125,Ca153 and Cyfra211 was associated with prognosis. The possibility of one year survival was small as long as there was high level of TM above.8 It is more rational choosing TCM as treatment programm with regard to patients with advanced cancer or venerable age.Conclusion:It is of great significance that measuring rational combined multiple serum tumour markers on judging pathologic category and selecting the treatment programm. |
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