| ObjectiveDrug-resistant bacterial infections has become a major issue to be solved in the medical profession, only using antibiotics and synthetic antibacterial drugs can not be settled. TCM has great advantages in anti-infective treatment. Previous studies pay more attention to the therapy of clearing away heat and poison than the therapy of tonifying and expelling evil. This study, subjected by the special topics of major national science and technology support funded projects,will dig out the TCM theory of curing clinically refractory fever caused by drug-resistant PA by the ancient classics and modern literature research.It is going to investigate tonifuing and evil-expelling herbs-Qi Gui Yin Fang and its compatibility of medicines and Pharmacology. Reveal the therapy of tonifying and expelling evil for clinical treatment of drug-resistant PA infection by conducted by clinical retrospective study. Studying Qi Gui Yin Fang for the inhibition of PA builds the foundation for following clinical and the experimental study.MethodsFirst of all, by referencing the ancient books, analyzing drug-resistant bacterial infections explains the directive function of TCM which is used to cure clinically refractory fear caused by drug-resistant bacteria. Using TCM theory explains Qi Gui Yin Fang which resist the refractory fever caused by bacterial infection in pharmacological aspects of modern medicine mechanism. Then, using the application of clinical retrospective study observes the epidemiological of drug-resistant PA in ICU in 2007 and its basic syndromes. Comparing mortality and other indicators between the treatment set which group by which is applied early to tonifuing and evil-expelling herbs and APECHAâ…¡Point scale explores the therapy for drug-resistant PA infection. Finally, using the application of serum pharmacological method conducts the function of suppressing PA which regard with Qi Gui Yin FangResultsThe fundamental research indicates the pathogenesis characteristic of "Fu Xie" and the characteristic of drug-resistant bacterial infections to be the same, its principle of treatment is useful to remedy drug-resistant bacterial infections.The clinical investigation discovers the advanced age and the application life-support machine are the infection high-risk factors, APECHA II Point scale has a positive correlation with mortality rate inseparably, PA have a higher resistance to various antibiotics. The patient in the low danger APACHE II group who is applied early to tonifuing and evil-expelling herbs have lower mortality rate than the control group obviously.The experimental study has proven PA's MIC of Qi Gui Yin Fang medicine blood serum group is lower than the MIC of Blank blood serum group obviously. It explains Qi Gui Yin Fang to be able the bacteriostasis. By comparing various consistencies' groups with the blank group contrast, the low monitoring team is separately remarkable.Conclusions1 "Fu Xie" theory is meaningful in the clinical treatment of drug-resistant bacterial infections. The meaning of Qi Gui Yin Fang conforms to the principle of "Fu Xie" theory.2 In clinical observation, using tonifuing and evil-expelling herbs early in the low danger APACHEâ…¡group have the improvement prognosis function in the treatment, making a counter-evidence that patients has often had the lacking in qi and yang in the infection disease, will guide the therapy for curing refractory infection by using TCM.3 Study found that drug-containing serum to inhibit the growth of PA, it is because the drug to promote the physical own reaction inhibition probably.4 The blood serum Pharmacology method is suitable for TCM research, it is a reliable testing method in TCM vitro bacteriostasis experiment. |
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