Study On The Synthesis Of 1H-isochromene Derivatives And Furan-2(5H)-ones

Benzohetercyclic rings can be found in many natural occurring products, which are commercially important in pharmaceuticals. Compounds containing those frameworks are also considered as building blocks for the construction of numerous compounds. Therefore, many organic chemists focus their interest on the synthesis of this class of compounds.Tandem reactions, which are referred to as one-pot synthesis in situ, provide a powerful tool to rapidly synthesize diverse and complex heterocyclic compounds. Such processes are efficient and environmentally benign.The 2(5H)-furanone moieties are prevalent in a variety of natural products and medicinally important compounds. There is an intrinsic need for routes to the expedient synthesis of diverse 2(5H)-furanone derivatives under mild conditions and simple catalytic system.This dissertation is mainly consists of the following two Parts: 1) developed novel strategies for the construction of 3-(1H-isochromen-1-yl)-1H-indoles through tandem reactions between 2-alkynylbenzaldehydes and indoles. Progresses on tandem reactions of 2-alkynylbenzaldehydes during last several years were also reviewed. 2) 3,4-disubstituted-2(5H)-furanones were efficiently synthesized from tetronic acid.