Studies On The Synthesis And Applications Of α-Alkenoyl Ketene-(S,S)-acetals

Synthesis of heterocyclics have been extensively investigated as medicine and versatile intermediates in the synthesis of multi-functional complex molecules and natural products. N-Substituted pyridone compounds have versatile physiological activity. For instance, they can sterilize, ease pain, resist tumour and cure parkinsonism and so on. These compounds have powerful ability to form coordination compounds, which can cureβ-thalassemia beyond compare. The ramification of N-Substituted pyridone can be made to drug precursors.a-oxo ketene-S,S-acetals has taken an important place in the field of organic synthesis through many years hardwork by scientists. This article based on the a-enoyl ketene-S,S-acetals. Through Schiff-base strategy and Lewis acid catalytic annelation reaction, we synthesized a series of p yridone compounds and found out its synthesis method. This new method established a new synthesis way of pyridone compounds, which had extensive universal property and brief step. What's more, this method had established a foundation for the compounds in the same category in the use of the pharmaceutical chemistry.