Synthesis And Improvement Of 3-amino-6-chloro-4-methylpyridine

6-chloro-3-amino-4-methylpyridine, First appeared as a by-product in the production of nevirapine intermediate 2-chloro-3-amino-4-methylpyridine that has been established to be clinically useful for the treatment of infection by HIV. Later, with the developing of pharmaceutical chemistry, the scientists found that 6-chloro-3-amino-4-methyl pyridine is useful in the field of drug, these drugs could be used to treat rheumatoid arthritis,cardio-cerebral vascular infarction,nervous system diseases. Although there are several articles about the synthesis of the compound in other countries, But the study of the synthesis process have not been reported. So in order to find a more mature synthesis method about the compound,2-amino-4-methylpyridine used as raw material and through a series of reactions to research it.The first part of the paper introduces the development of pyridine compounds history and the application. On this basis, I illustrated the synthetic research and application of the 3-amino-6-chloro-4-methyl pyridine detailedly. Finaly I put forward my own synthesis method and research route.The second part of the paper successfully synthesize 6-chloro-3-amino-4-methyl pyridine on the basis of the schedule of synthetic route and study the separation and structure detection of each product. Finally I get the target product in a higher yield and make the purity of the target product to 99.2%.The third part of the paper optimized each step reaction process, and focused on the separation methods of the isomers between 2-amino-3-nitro-4-methylpyridine and 2-amino-4-methyl-5-nitro pyridine, and evaluated all kinds of the separation methods. At Finally, I found out the better synthesis method of the target product.The fourth part of the paper summarized the better process conditions of the synthesis metheds, at the same time provided ideas about the further improvement of it.