The Preparation Of Composite Inorganic Hollow Spheres With Hydrophobic Inner Surface And Application For The Drug Delivery

Recently, drug slow releasing technology has become to be a important role in the modern medicine. But it is always difficult to control the release of drug. Inorganic hollow microspheres drug slow-release has a lot of field application prospect due to its unique internal cavity and porous structure, good stability, and the surface is easy to modify modification. In order to obtain the new drug carrier which have a big drug loading, good biocompatibility, stability analysis of structures and good slow-release effect. Therefore, hollow microspheres with hydrophobic inner surface and hydrophilic surface are synthesized. And the magnetic targeted materials are also synthesized in this paper. Herein, their drug release behaviors have been investigated.1. Prepared the SiO2-C18-PC/TiO2hollow spheres. Using calcium carbonate microspheres as templates, prepared SiO2hollow microspheres. SiO2hollow spheres were modified by18alkyl methylerichlorosilane (SiO2-C18), Then the surface of the SiO2-C18adsorb a layer of lecithin(SiO2-C18-PC), Finally the surface of SiO2-C18-PC coating a layer of complete titanium dioxide (SiO2-C18-PC/TiO2), achieve its external surface close water conversion. Electron microscopy and nitrogen adsorption/desorption results show that it has a complete cavity structure and porous shell structure, and have a good hole size distribution. Using fat-soluble ibuprofen (IBU) as a model drug, the investigation of drug release rates of the SiO2-C18-PC/TiO2shows that SiO2-C18-PC/TiO2have a good drug slow-release effect due to introduction of hydrophobic groups, as they have certain adsorption reaction with the hydrophobic drug, which let the release rate slower.2. Prepared the SiO2-C18-PC/Fe3O4hollow spheres. Using SiO2-C18-PC as templates, coating a layer of complete Fe3O4shell in different way. It was not only can make the close water appearance get further solidify, but also let it with magnetic ability which has a good application prospect in the field of targeted drug release. Using fat-soluble ibuprofen(IBU) as a model, the investigation of drug release rates of the SiO2-C18-PC/Fe3O4shown that the modified SiO2-C18-PC/Fe3O4exhibit lower release rate due to the hydrophobic effect.3. For further study the effect of the selective modification on drug release, SiO2-C18-C18/SiO2hollow spheres have been synthesized. Using different kinds of amphoteric molecules(PC,CTAB,C18) as the hydrophilic convert agent, the investigation of the experimental results show that use C18as the convert agent, have a wonderful transformation effect and inorganic layer coated effect.