The Investigation Of The Level Changes Of Serum YKL-40 And Lp-PLA2 In ACS Patients And Its Relationship With ACS Short-term Prognosis

Objective:The aim of the study was to examine the level changes of serum YKL-40 and Lp-PLA2 in patients with acute coronary syndrome, and investigate the association of serum YKL-40 levels and Lp-PLA2 levels with short-term prognosis of patients with acute coronary syndrome.Methods:A total of 126 in-hospital patients who from the department of cardiology of the XiangYa hospital during Sep 2010 to Feb 2011 and 25 healthy controls was recruited in this study. Serum YKL-40 levels and Lp-PLA2 levels were measured by ELISA method on day 1 and day 7 after admission. ALL patients were followed up for 3 months. Results:(1)Both serum YKL-40 levels and Lp-PLA2 levels in patients with CHD were significantly higher than those patients in control group(P＜0.001), and both serum YKL-40 and Lp-PLA2 levels in patients with ACS were significantly higher than those in patients with SAP. (2) Both serum YKL-40 and Lp-PLA2 levels were measured on day 7 after admission were significantly lower than those were measured on day 1 after admission(P<0.001). (3) We found no significantly association between both serum YKL-40 and Lp-PLA2 levels and the number of stenosed vessels in patients with ACS(P>0.05). (4) Binary logistic regression analysis showed that serum YKL-40 are risk factors of ACS short-term prognosis, high levels of YKL-40 indicates a poor prognosis (P=0.017,OR 20.123,95%CI 1.721～235.321)Conclusions:1. Both serum YKL-40 levels and Lp-PLA2 levels in patients with ACS were significantly higher than those in patients with SAP and in control group; 2. Both serum YKL-40 and Lp-PLA2 levels were not correlated with the number of stenosed vessels in patients with ACS;3. High serum YKL-40 levels is association with poor prognosis in patients with acute coronary syndrome.