Expression And Significance Of Serum Soluble Tumor Necrosis Factor Receptor In Patients With Laryngeal Cancer

Objective: To explore its clinical significance in the diagnosis and monitoring of laryngeal cancer the changes of serum soluble tumor necrosis factor receptors (sTNFR) levels in patients with laryngeal cancer were detectedMethods: The serum levels of sTNFRⅠand sTNFRⅡwere detected by avidinbiotin complex enzyme-linked immunosorbent assay (ABC-ELISA) in 40 healthy adults and 42 patients with laryngeal cancer before and after operation at different time .Results: The serum level of sTNFRⅠin laryngeal cancer patients (1463.34±669.07pg/ml)was significantly higher than that in the control group(549.30±293.29pg/ml)(P<0.05), while compared with control group the sTNFRⅡlevel showed no significant difference (P> 0.05); There was no significant difference among the levels of sTNFRⅠand sTNFRⅡin different types of laryngeal cancer(P>0.05), there was significant difference in the sTNFRⅠlevel at the various developing periods of laryngeal cancer(P<0.05),and the change of sTNFRⅡlevel in the various periods of laryngeal cancer was of no significant difference (P>0.05). The sTNFRⅠlevel of laryngeal cancer patients with lymph node metastasis was much higher than that of the patients without lymph node metastasis (P <0.05).There was no the significant difference in sTNFRⅡlevel between patients with lymph node metastasis and those without lymph node metastasis (P> 0.05). The serum sTNFRⅠlevel in laryngeal cancer group was significantly lower than that in patients before operation on the seventh day after surgery, but it was significantly higher than that in the control group (P <0.05). One month after surgery , the serum sTNFRⅠlevel in laryngeal cancer group was significantly lower than preoperative levels(P<0.05), and there was no significant difference with the control group (P> 0.05). Conclusion:1)The detection of serum levels of sTNFRⅠhas practical value in the early diagnose and estimating prognosis of laryngeal cancer.2)The detection of serum levels sTNFRⅠhas guiding significance in diagnose cervical lymph node metastases of laryngeal cancer.