Dredging Method In The Treatment Of Diabetes Fundermental Peripheral Neuropathy Clinical Research

Purpose:Discuss TCM for diabetic peripheral neuropathy (DPN) understanding, and using the method of qi qi and Yin alleiating DPN stubborn reluctance two empty, blood stasis syndrome. The clinical study of collaterals Through randomized controlled clinical trial, observation of qi and Yin DPN two empty, blood stasis resistance syndrome patients blood sugar and collaterals glycosylated hemoglobin (HbA1C), lower limb nerve conduction velocity, hemorheology examination indexes to change, and evaluate its effectiveness and safety, and discusses the prevention for clinical disease mechanism, the wide use of provide objective basis.Methods:Using randomized method, will meet two empty, qi and Yin DPN blood stasis syndrome diagnosis standard reluctance winding patients were randomly divided into the control group, the treatment group, the treatment group and to clear away sugar bi-complex square water decoction, daily a dose of treatment; The control group to oral "insurable 0.5 g,3 times a day.4 weeks for 1 treatment, a total of two treatment observed. Evaluate separately two groups before and after treatment, the clinical symptoms, signs of change, and observed blood sugar, glycated hemoglobin (HbA1C), lower limb nerve conduction velocity, hemorheology, etc, and the patient monitoring indicators of adverse reactions and compliance. All data using the statistical analysis SPSS 17.0 statistical software.Results:Confirm DPN qi and Yin and incorporate two empty, blood stasis resistance winding 60 cases (syndrome patients 30 cases in treatment group and control group,30 cases), before treatment age, duration of two groups of patients after statistics processing baseline data such as no significant difference, two sets of data (P>0.05 comparable. Therapeutic indexes of the comparison results:(1) the signs and symptoms improved:treatment group symptoms improved after treatment, the total effective rate of 90.00%, the comparison group total effectiveness for 53.33%. The treatment group TCM symptoms, signs improvement than in control group (P< 0.01). (2) the hypoglycemic effect:treatment group patients fasting blood glucose, blood sugar,2-hr HbA1C control and HbA1C than before treatment with both dropped significantly (P<0.01), the control group patients fasting blood glucose, blood glucose after a meal is 2 hours before treatment have difference (P<0.05). The treatment group patients fasting blood glucose, blood sugar,2 hours after a meal is glycosylated hemoglobin improvement group compared with difference (P< 0.05). (3) lower limb nerve conduction velocity:treatment group patients bilateral phil total motor nerve, sensory nerve conduction velocity, amplitude are relatively before treatment improved significantly (P< 0.01); The control group patients peroneal motor nerve, left sensory nerve conduction velocity is improved before treatment (P< 0.01), the right phil total sensory nerve volatility is before treatment improved significantly (P< 0.01), but the improvement over are not obvious (P> 0.05). Comparison between groups, the treatment group patients bilateral peroneal motor nerve, sensory nerve conduction velocity, amplitude improve are better than the control group (P<0.05 or P< 0.01). (4) hemorheology:after treatment, the two groups of whole blood viscosity (high cut, cut, cut in plasma viscosity, lower than before treatment are decline significantly (P< 0.01); The treatment group whole blood viscosity (high cut, cut) improve more in control group have difference (P< 0.05), whole blood viscosity (low cut) improve no obvious difference than the control group, the two groups after treating plasma viscosity improve no difference obvious (P> 0.05).Conclusion:From the preliminary clinical research and analysis, clear away sugar can improve polio-free, qi and Yin DPN party two empty, blood stasis syndrome patients treasure-the resistance of clinical symptoms, signs, reducing blood sugar, improve nerve conduction velocity and SOD, improve the body anti-oxydation ability, still can influence blood rheology safe, effective, and has wide application prospects and deserves further study.