Basic Research On The Construction And Application Of Real-time Monitoring Models In Radiofrequency Ablation

As an important method in the treatment of Parkinson's disease, radiofrequency ablation is still far from perfect, for instance, lacking in acquiring optical properties of biological tissue, hard to evaluate the efficacy with quantized factors and so on, which make against to the safety and accuracy of the operation. This paper raises a concrete proposal to settle the problems above. Collecting the optical properties by using near infrared spectroscopy and creating volume models of effective lesions from simulation and experiments, which get rid of blindness and low accuracy, provide references for the application of radiofrequency and lay the groundwork for future treatment of Parkinson's disease.Firstly, this paper simulates the temperature distribution of mice brain with radiofrequency ablation by using finite element analysis software according to the application of finite element method to bio-heat transfer. Secondly, the author deduced the volume model based on the simulation. The temperature distribution model decided instantaneous temperature at any position of the mice brain while the volume model decided the size of effective lesions at any time and temperature. At the same time, a large number of experiments are made to validate the proposal. Experimental volume model and reduced scattering coefficient (μs′) model are presented resulted from the outcome. The former is to prove the efficiency of the simulation while the latter is used to be the real-time monitoring model which can evaluate the level of ablation.The creativeness of this study is as follows: (1) present the simulation models based on finite element method, including temperature distribution model and volume model of effective lesion, (2) create the experimental volume model and reduced scattering coefficient (μs′) model, validate the efficiency of simulation and lay the groundwork for treatment of Parkinson's disease, (3) advance the idea of efficacy assessment, design the real-time monitoring method by usingμs′, get rid of blindness and low accuracy, provide references for the application of radiofrequency.