| Objective:To explore the efficiency of Ke Liu Wan combined with chemotherapy in advanced colorectal carcinoma patients, investigate the local tumor size, clinical symptom amelioration, the tumor marks, the inhibition of expression of serum VEGF-A,VEGF-C and observe the safety.Methods:55 cases of advanced colorectal carcinoma were randomly divided into 2 groups, test group (Ke Liu Wan with chemotherapy) and control group (chemotherapy alone), and the clinical and pathological effects were compared with each other. Otherwise sample VEGF before and after treatment respectively, then used the quantitative sandwich enzyme immunoassay technique to assay serum VEGF-A and VEGF-C. At last analyse the relation about clinical effect with expression of serum VEGF-A and VEGF-C.Result:1. In clinical effect, RR of the test group is 35.71%, significantly higher than the control group, there is not significant differences (P>0.05).2. In symptom improvement, the effective rate of the test group is 67.86%, significantly higher than the control group. After treatment, patients of the test group with fatigue is much better than the control group by statistical analysis, there is significant differences (P<0.05).3. In KPS, the control rate of test goup is 82.14%, which is higher than the control group, there is significant differences (P<0.05).4. After treatment, the tumor marks in two group has no significant differences (P>0.05).5. The expression of serum VEGF-A of test group is 261.95±62.05pg·ml-1, which is significantly lower than those before treatment, the difference has meaning in the statistics (P<0.05); compared with the control group is significantly lower, but the difference has no meaning in the statistics (P>0.05). After treatment, the expression of serum VEGF-C of test group is 163.62±30.68 pg·ml-1 which is significantly lower than those before treatment, and also lower than the control group, but the difference has no meaning in the statistics (P>0.05). Otherwise there is relationship between expression of serum VEGF-A and VEGF-C which Pearson shows:r= 0.366. 6. The number of cases of appearing bone marrow suppression and liver or kidney damage in the test group are lower than the control group after treatment, but the difference has no meaning in the statistics (P>0.05).Conclusion:Ke Liu Wan combined with chemotherapy is more effective in treating advanced colorectal carcinoma. It can enhance the effect of chemotherapy, relieve the toxic response and side effects caused by chemotherapy, stable the tumor, ameliorate living quantity and prolong the life span.Otherwise, Ke Liu Wan can suppress the expression of serum VEGF-A. |
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