Midazolam Combined With Propofol In The Application Of Painless Gastroscopy

ObjectiveTo study the small dose of midazolam combined with propofol in painless gastroscopy feasibility and safety.MethodsSelect voluntary painless gastroscopy ASAⅠ-Ⅱoutpatients level 120 cases were randomly divided into control group (A group) and the observation group (B group). Observation group (60 patients) low dose midazolam (approximately lmg) and propofol induction of anesthesia, the control group (60 cases) to give 0.9% sodium chloride solution and propofol. Until loss of eyelash reflex, and call after gastroscopy should not. Inspection, if the patient is not awake or conscious actions to the initial dose of 0.3-0.5mg/kg of additional propofol, oxygen saturation below 90% oxygen mask pressure, HR below 60 beats/min, injection of 0.5mg atropine. Observation of blood pressure, breathing changes. Anesthesia induction time the two groups, the dose of propofol; before administration 5min (T1), after administration of 3min (T2), the beginning of endoscopy (T3), check for 5min, (T4), check the end of 5 minutes (T5) of the systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), oxygen saturation (SPO2); patients with and without surgery in poor memory, and vomiting after the hospital stay awake.Results120 cases of patients were to complete the inspection. Group B induction time shorter than the A group (P<0.05), and less than the dose of propofol A group (P <0.01). With baseline (T1) compared, T2-T5 point in time the two groups of SBP, DBP, HR was lower than T1 (P<0.05), the largest decline of which point in time T3, but the SBP decreased by less than 20%, DBP, HR Reduce the rate of less than 15% and; with A group, B group T3 point HR, SBP higher (P<0.05). Patient had surgery two bad memory, nausea and vomiting occurred less than the number of group A group B, but no significant difference (P> 0.05), awakening time was no difference in the two groups (P>0.05). B group of patients A hospital stay were significantly higher than head (P<0.05).ConclusionThis study shows that a small dose of midazolam combined with propofol for painless endoscopy, anesthesia induction time was significantly shortened, reducing the dose of propofol, the more stable vital signs, no intraoperative bad memory, However, hospital stay a little longer. It is suggested that a small dose of midazolam combined with propofol is safe and effective for painless gastroscopy.