A Study Of The Application Of Speckle Trackin Imaging To Right Ventrlcular Function In Type2 Diabetes Mellitus

PART one Evaluation on right ventricular systolic function in patients with type 2 diabetes mellitus using two-dimensional speckle tracking imaging of tricuspid annular displacementObjective To estimate the clinical value of tricuspid annular displacement (TAD) with two-dimensional speckle tracking imaging technique in the assessment of right ventricular systolic function in patients with type 2 diabetes (T2DM). Methods Fourty-four patients with T2DM (19 with DM only[T2DMⅠgroup] and 25 patients with coexisting DM and microangiopathy[T2DMⅡgroup]) as well as 28 healthy subjects (control group) were enrolled. Two-dimensional (2DE) and real-time three-dimensional imaging were obtained all at the apical four-chamber view. The TAD parameters including TAD at the right ventricular free wall (T1), TAD at the interventricular septum(T2), TAD at the midpoint of tricuspid annulus(Tm) and the right ventricular longitudinal shortening(Tm%) were obtained using off-line QLAB7.0 software, while left and right ventricular ejection fraction(LVEF, RVEF) were calculated by using TOMTEC software. Results The Tm%, LVEF and RVEF were significantly lower in T2DM I group than those of control group(all P< 0.05). T1, T2, Tm and Tm% were significantly lower in T2DMⅡgroup than in control group(all P<0.05).LVEF and RVEF in T2DMⅡgroup decreased significantly compared with control group(both P<0.05). T1, T2, Tm and Tm% were significantly lower in T2DM II group than T2DM I group (all P< 0.05).The parameters of TAD correlated positively with RVEF, r =0.72(T1),0.68(T2),0.78(Tm) and 0.94(Tm%), respectively. Conclusions Based on STI, TAD is a novel, non-invasive parameter which may be used in detection of right ventricular systolic dysfunction in patients with T2DM.PART two Evaluation on right ventricular function in patients with type 2 diabetes mellitus using two-dimensional speckle tracking imagingObjective To estimate the clinical value of two-dimensional speckle tracking imaging technique in the assessment of right ventricular function in patients with type 2 diabetes (T2DM). Methods Fourty-four patients with T2DM (19 with DM only[T2DMⅠgroup] and 25 patients with coexisting DM and microangiopathy[T2DMⅡgroup]) as well as 28 normal control group were collected. Two-dimensional (2DE) imaging were obtained at the apical four-chamber view. Peak systolic strain and strain rate of all segments in right ventricular free wall were obtained using off-line QLAB7.0 soft ware. Results Compared to the control group, SRs and Sre in all of the segments in right ventricular free wall were significantly lower in T2DMⅠgroup, as the same asεand SRa in the basal segment in T2DMⅠgroup(all P<0.05),ε, SRs, SRe,SRa in all of the segments in right ventricular free wall were significantly lower in T2DMⅡgroup(all P<0.05);ε,SRs,Sre in the basal segment were significantly lower in T2DMⅡgroup than T2DMⅠgroup ((all P<0.05).Conclusions STI is a non-invasive technique which may be used in detection of right ventricular function in patients with T2DM.