Mri Diagnosis Of Brain Multiple Sclerosis And Its Diffusion Tensor Imaging Study Of The Normal-appearing Gray Or White Matter

Objective :Investigate the MRI characterized represent in the brain of multiple sclerosis and analysis of relevant clinical data, to improve its image diagnosis. Methods:Conventional scanning with T1WI, T2WI, Flair and DWI sequences, parallel Gd-DTPA enhanced MRI to the 36 patients of simple brain or cerebrospinal mixed MS. Analyze the characteristics of brain plaque and brain atrophy ,analyze the relevance of EDSS score and clinical data .Results :In 36 cases of MS patients, the predilection site followed by are lateral ventricles side, brain stem, corpus callosum, centrum semiovale, basal ganglia, cortical or subcortical white matter, cerebellum. 16 cases is whole brain atrophy ,and 1 case is the cerebellum atrophy where the lesions located. Compare the EDSS score between Simple brain damage and cerebrospinal mixed damage of MS patients was statistically significant (P <0.05), the total EDSS score was positively correlated with the course of diseases (r = 0.42, p = 0.0257). Conclusion :MRI features of MS patients have specific manifest,and will provide evidence to the clinical diagnosis and follow-up diagnosis . Objective:The purpose is using diffusion tensor imaging quantitative analysis of multiple sclerosis patients whether there is delitescence damage in normal-appearing gray matter and white matter.Methods:Comparing routine MRI and DTI of 36 cases followed up diagnosed MS patients group and 20 cases sex and age matched healthy control group, comparing and analysing the apparent diffusion coefficient(ADC) and the fractional anisotropy(FA)in the different anatomical parts between the two groups, including the analysis of conventional T2WI as seemingly normal appearing cortical gray matter (NACGM), deep gray matter nuclei (NADGM) and the performance of normal white matter (NAWM), and analyse the score of relevance of these indicators and Expanded Disability Status Scale (EDSS). Results :ADC value of MS patients'NACGM area is increased, FA values decreased. NADGM area only had significant changes of FA values in thalamus, The forehead lobe and occipital lobe of NAWM areas showed diffuse increase in ADC values, FA values decreased. FA value of Occipital white matter were negatively correlated with the EDSS score.The ADC of Posterior limb of endocorpus were positively correlated with the time that the symptom lasting.FA value of thalamus is negatively correlated with the course of disease.Conclusion Conventional MRI showed the existence of microstructural damage in normal-appearing brain gray and white matter.DTI can be used as sensitiwity indicators that reflect the micro-pathological changes of MS patients.